Value of detection of serum human epididymis secretory protein 4 and carbohydrate antigen 125 in diagnosis of early endometrial cancer of different pathological subtypes.
Value of detection of serum human epididymis secretory protein 4 and carbohydrate antigen 125 in diagnosis of early endometrial cancer of different pathological subtypes.
复制标题
血清人附睾分泌蛋白4和糖抗原125检测对不同病理亚型早期子宫内膜癌的诊断价值
DOI：
10.2147/ott.s81853
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发表时间：
2015
影响因子：
4
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Liu X;Zhao F;Hu L;Sun Y
本研究探讨血清中检测人附睾分泌蛋白4 （HE4）和碳水化合物抗原125 （CA125）对不同病理亚型早期子宫内膜癌的诊断价值，并探讨HE4和CA125在诊断中的作用机制。本研究采用酶联免疫吸附法和化学发光免疫法检测子宫内膜癌和对照组血清HE4和CA125。比较两组患者HE4、CA125的浓度，分析CA125、HE4的表达及子宫内膜癌患者的临床病理特征。与对照组相比，子宫内膜癌患者血清中HE4的表达明显升高，而CA125的表达无明显变化。通过接收机工作特性分析法获得阈值检测值，分别为141.5 pmol/L和54.5 U/L。子宫内膜癌早期（I期）患者HE4浓度与健康人比较，差异有统计学意义，CA125无明显差异。HE4、CA125在ⅰ期和ⅱ期子宫内膜癌诊断中的意义比较，差异无统计学意义。ⅱ、ⅲ期患者HE4水平差异有统计学意义，CA125水平差异无统计学意义。HE4和CA125特异性均为95%，且HE4对子宫乳头状浆液性癌的敏感性高于对子宫内膜样腺癌的敏感性。因此，血清HE4检测子宫内膜癌的早期诊断效果明显优于CA125。
This study explored the value of detection of human epididymis secretory protein 4 (HE4) and carbohydrate antigen 125 (CA125) from serum in diagnosis of early endometrial cancer of different pathological subtypes and discussed the mechanism of HE4 and CA125 in diagnosis. In this study, enzyme-linked immunosorbent assay and chemiluminescent immunoassay were used to detect HE4 and CA125 from serum in endometrial cancer and control groups. Besides, the concentration of HE4 and CA125 was compared in these two groups, and the expression of CA125 and HE4 and clinicopathological characteristics in patients with endometrial cancer were also analyzed. Compared with the control group, the expression of HE4 was much higher in serum of patients with endometrial cancer, while there was no obvious change in the expression of CA125. The threshold detection value was acquired by receiver operating characteristic analysis method, that is, 141.5 pmol/L and 54.5 U/L, respectively. When comparing the concentration of HE4 in patients with endometrial cancer at the early stage (stage I) with healthy people, the difference therein had statistical significance, but there was no obvious difference in CA125. HE4 and CA125 in diagnosis of endometrial cancer in the stages I and II were found with no statistically significant difference. The difference of HE4 in the stages II and III had statistical significance while the difference of CA125 had no statistical significance. The specificity of both HE4 and CA125 was 95%, and the sensitivity of HE4 to uterine papillary serous carcinomas was higher than that to endometrioid adenocarcinoma. Thus, the serum HE4 is much better than CA125 in detecting the endometrial cancer at an early stage.