VENTILATORY AND WAKING RESPONSES TO HYPOXIA IN SLEEPING DOGS
VENTILATORY AND WAKING RESPONSES TO HYPOXIA IN SLEEPING DOGS
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DOI：
10.1152/jappl.1978.44.4.512
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发表时间：
1978-01-01
影响因子：
3.3
通讯作者：
KOZAR, LF
中科院分区：
文献类型：
--
作者：
PHILLIPSON, EA;SULLIVAN, CE;KOZAR, LF
对4只犬在自然睡眠中对急性缺氧的觉醒和呼吸反应进行了研究。通过重复呼吸法将肺泡二氧化碳分压(PACO2)维持在真核水平，诱导进行性低氧。用耳氧仪测量动脉血氧饱和度(SaO2)，根据脑电和行为指标判断睡眠阶段。在SaO2为87.5.+-时，从真核低氧中唤醒。2.6%(平均+-Se)，在慢波睡眠(SWS)时，SaO2为70.5+-。快速眼动睡眠时3.4%(P<；0.005)。在低氧期间，典型的快速眼动睡眠的不规则呼吸模式持续存在。对每一次呼吸的瞬时每分钟通气量(.ovrhdot.VI)与SaO2的线性回归分析显示，REM睡眠中的回归系数与SWS和清醒中的相似。这一发现与早期观察到的.ovrhdot.VI在快速眼动睡眠期间对二氧化碳的反应减弱形成了鲜明对比。尽管在REM睡眠中，对缺氧的觉醒反应会延迟，但呼吸反应保持完好，因此在这个睡眠阶段保持足够的通风可能是很重要的。
Waking and ventilatory responses to acute hypoxia in 4 dogs during natural sleep were studied. Progressive hypoxia was induced by a rebreathing technique in which alveolar CO2 pressure (PACO2) was held at the eucapnic level. Arterial O2 saturation (SaO2) was measured with an ear oximeter, and sleep stage was determined by EEG and behavioral criteria. Arousal from eucapnic hypoxia occurred at a SaO2 of 87.5 .+-. 2.6% (mean .+-. SE) during slow-wave sleep (SWS), and at a SaO2 of 70.5 .+-. 3.4% during rapid eye movement (REM) sleep (P < 0.005). The irregular pattern of breathing typical of REM sleep persisted during hypoxia. Linear regression analysis of breath-by-breath instantaneous minute volume of ventilation (.ovrhdot.VI) against SaO2 revealed regression coefficients in REM sleep that were similar to those found in SWS and wakefulness. This finding contrasts with earlier observations of a decreased response of .ovrhdot.VI to CO2 during REM sleep. Although waking responses to hypoxia are delayed in REM sleep, ventilatory responses remain intact and therefore may be of importance in maintaining adequate ventilation during this stage of sleep.