Formation of bradykinin in anaphylactic and peptone shock.
Formation of bradykinin in anaphylactic and peptone shock.
复制标题
过敏和蛋白胨休克中缓激肽的形成。
DOI：
10.1152/ajplegacy.1950.163.2.283
复制
发表时间：
1950
影响因子：
--
通讯作者：
Beraldo Wt
中科院分区：
文献类型：
--
作者：
Beraldo Wt
Peptone Shock. Twenty dogs were injected intravenously with IO per cent Bactoprotone solution, in doses of 0.5 to 5 cc/kg. The solution was boiled for IO minutes, cooled and shaken with permutit in order to remove traces of histamine. Bradykinin activity was present in the blood of 17 out of 20 dogs after peptone shock, ranging between 30 to 120 pg. of bradykinin standard per cc. of blood. In peptone shock as in anaphylaxis the bradykinin activity bears no relationship to the amount of histamine released or to the severity of the shock. Figure I shows a blood pressure tracing during peptone shock and contractions of guinea pig ileum after additions of blood samples to the bath before and at several intervals after the injection of peptone. The maximum activity is shown to be attained at go minutes. The blood samples withdrawn later show progressively decreasing activity which finally disappears.A powder obtained by alcoholic extraction of plasma drawn from a dog during peptone shock produces a fall in blood pressure in dogs and rabbits. In one experiment only traces of active substance could be detected in the blood after 0.5 cc/kg. of peptone. After recovery from the first shock a second injection of 1.5 cc/kg. produced activity equivalent to 30 pg. of bradykinin/cc. of blood. The blood pressure fell 50 mm. Hg. This experiment can be understood on the basis of a direct action of peptone on the globulin in the animal body, eliciting the formation of bradykinin by a mechanism apparently independent of the liberation of stored substances such as histamine and heparin, which may be depleted by the first shock so that little may be left for subsequent reactions. Furthermore, the fact that a larger dose of peptone produces larger amounts of active substance when injected in the same animal suggests that the blood activity can be related to the amount of peptone injected, another fact supporting the hypothesis of direct action of peptone on the globulin.
