Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion
Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion
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DOI：
10.1016/j.bbrc.2010.11.075
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发表时间：
2011-01-07
影响因子：
3.1
通讯作者：
Kwon, Young-Guen
中科院分区：
文献类型：
--
作者：
Rho, Seung-Sik;Choi, Hyun-Jung;Kwon, Young-Guen
Clec14a是血栓调节蛋白（TM）家族的成员，但其功能尚未确定。在这里，我们报道 Clec14a 是一种内皮细胞 (EC) 的质膜蛋白，在小鼠血管系统中特异性表达。缺失突变体分析表明，Clec14a 通过其 C 型凝集素样结构域介导细胞间粘附。 EC 中 Clec14a 的敲低抑制了细胞迁移活性和丝状伪足突出，并延迟了管状结构的形成。这些发现表明 Clec14a 是一种新型 EC 特异性蛋白，似乎在细胞间粘附和血管生成中发挥作用。 (C) 2010 Elsevier Inc. 保留所有权利。
Clec14a is a member of the thrombomodulin (TM) family, but its function has not yet been determined. Here, we report that Clec14a is a plasma membrane protein of endothelial cells (ECs) expressed specifically in the vasculature of mice. Deletion mutant analysis revealed that Clec14a mediates cell-cell adhesion through its C-type lectin-like domain. Knockdown of Clec14a in ECs suppressed cell migratory activity and filopodial protrusion, and delayed formation of tube-like structures. These findings demonstrate that Clec14a is a novel EC-specific protein that appears to play a role in cell-cell adhesion and angiogenesis. (C) 2010 Elsevier Inc. All rights reserved.