Anti-atherogenic mechanisms of high density lipoprotein: effects on myeloid cells.
Anti-atherogenic mechanisms of high density lipoprotein: effects on myeloid cells.
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DOI：
10.1016/j.bbalip.2011.08.003
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Tall AR
中科院分区：
文献类型：
--
作者：
Murphy AJ;Westerterp M;Yvan-Charvet L;Tall AR
在某些情况下，高密度脂蛋白（HDL）水平的增加与实验性动脉粥样硬化的减少有关。这在载脂蛋白A-I （apoA-I）转基因小鼠或注入HDL或其载脂蛋白的动物中最为明显。这些治疗被认为延缓动脉粥样硬化进展或导致其消退的主要机制是通过促进巨噬细胞泡沫细胞的胆固醇外溢。此外，高密度脂蛋白被描述为具有抗炎和其他有益作用。最近的一些研究将抗炎作用与胆固醇外排途径联系起来，但可能涉及多种机制。巨噬细胞胆固醇外排可能促进巨噬细胞从病变中迁移。虽然巨噬细胞可以通过多种途径介导胆固醇外排，但在敲除小鼠或细胞中的研究表明，ATP结合盒转运体（ABC） A1和G1介导的主动外排非常重要。除了在巨噬细胞中的传统作用外，这些转运蛋白还涉及造血干细胞增殖、单核细胞增多和中性粒细胞增多的控制，以及单核细胞和中性粒细胞的活化。因此，HDL和胆固醇外排途径可能在髓细胞/单核细胞/树突状细胞/巨噬细胞生命周期的所有阶段都具有重要的抗动脉粥样硬化作用。
In some settings increasing high density lipoprotein (HDL) levels has been associated with a reduction in experimental atherosclerosis. This has been most clearly seen in apolipoprotein A-I (apoA-I) transgenic mice or in animals infused with HDL or its apolipoproteins. A major mechanism by which these treatments are thought to delay progression or cause regression of atherosclerosis is by promoting efflux of cholesterol from macrophage foam cells. In addition, HDL has been described as having anti-inflammatory and other beneficial effects. Some recent research has linked anti-inflammatory effects to cholesterol efflux pathways but likely multiple mechanisms are involved. Macrophage cholesterol efflux may have a role in facilitating emigration of macrophages from lesions during regression. While macrophages can mediate cholesterol efflux by several pathways, studies in knockout mice or cells point to the importance of active efflux mediated by ATP binding cassette transporter (ABC) A1 and G1. In addition to traditional roles in macrophages, these transporters have been implicated in the control of hematopoietic stem cell proliferation, monocytosis and neutrophilia, as well as activation of monocytes and neutrophils. Thus, HDL and cholesterol efflux pathways may have important anti-atherogenic effects at all stages of the myeloid cell/monocyte/dendritic cell/macrophage lifecycle.
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DOI：
10.4049/jimmunol.0902372
发表时间：
2010-01-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Armstrong AJ;Gebre AK;Parks JS;Hedrick CC
通讯作者：
Hedrick CC
影响因子：
20.3
作者：
Gomes, Ana L.;Carvalho, Tania;Dias, Sergio
通讯作者：
Dias, Sergio
影响因子：
30.8
作者：
Bodzioch, M;Orsó, E;Schmitz, G
通讯作者：
Schmitz, G
具有遗传转换的高脂血症的逆转会影响动脉粥样硬化斑块中巨噬细胞的含量和炎症状态。
影响因子：
37.8
作者：
Feig JE;Parathath S;Rong JX;Mick SL;Vengrenyuk Y;Grauer L;Young SG;Fisher EA
通讯作者：
Fisher EA
影响因子：
15.9
作者：
Feig, Jonathan E.;Pineda-Torra, Ines;Fisher, Edward A.
通讯作者：
Fisher, Edward A.