Induction by topical corticosteroids of skin enzymes metabolizing carcinogenic hydrocarbons
Induction by topical corticosteroids of skin enzymes metabolizing carcinogenic hydrocarbons
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局部皮质类固醇诱导皮肤酶代谢致癌碳氢化合物
DOI：
10.1111/j.1365-2133.1973.tb06675.x
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发表时间：
1973
影响因子：
10.3
通讯作者：
M. Briggs
中科院分区：
文献类型：
--
作者：
M. Briggs;M. Briggs
用各种局部皮质类固醇软膏处理7天的小鼠匀浆的表皮芳烃羟化酶活性显著高于接受无类固醇软膏基质或未处理的动物的制剂。如通过3，4-苯并芘氧化测定的，通过腹膜内途径给予小剂量的各种多环烃后24小时，酶活性也大大增加。在体外添加7，8-苯并呋喃酮后，在对照组和给药组动物的皮肤匀浆中观察到酶活性抑制，但未观察到二甲亚砜。
Epidermal aryl hydrocarbon hydroxylase activity of homogenates from mice treated for 7 days with various topical corticosteroid ointments was significantly higher than in preparations from animals receiving steroid‐free ointment bases, or no treatment. As determined by 3,4‐benzopyrene oxidation, enzyme activity was also greatly increased 24 h after small doses of various polycyclic hydrocarbons given by the intraperitoneal route. Inhibition of enzyme activity was observed in skin homogenates from both control and treated animals following addition in vitro of 7,8‐benzoflavone, but not with dimethylsulphoxide.