The interactive effect of diabetes and central obesity on stroke: a prospective cohort study of inner Mongolians.
The interactive effect of diabetes and central obesity on stroke: a prospective cohort study of inner Mongolians.
复制标题
糖尿病和中心性肥胖对脑卒中的交互作用：内蒙古人的前瞻性队列研究
DOI：
10.1186/s12883-015-0328-y
复制
发表时间：
2015-04-28
期刊：
影响因子：
2.6
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Olofindayo J;Peng H;Liu Y;Li H;Zhang M;Wang A;Zhang Y
研究背景在糖尿病和非糖尿病人群中，中心性肥胖与脑卒中的关系并不一致。这表明糖尿病和中心性肥胖对中风风险的相互作用。本研究的目的是研究在队列的内蒙古人的相互作用。MethodsIn这个前瞻性队列研究中，我们评估了2003年6月和2012年7月之间的中风发病率糖尿病和中心性肥胖之间的相互作用。在基线时，从中国内蒙古招募并检查了2，589名成年人。根据糖尿病和/或中心性肥胖的存在，将参与者分为四个亚组。采用考克斯比例风险模型对加性和乘性相互作用进行评估。同时患有糖尿病和中心性肥胖的受试者的卒中累积发生率最高（对数秩检验，P= 0.042）。与既无糖尿病也无向心性肥胖的受试者相比，两种疾病的受试者中风的多变量校正风险显著更高（HR = 3.02，95%CI 1.24- 7.33，P =0.015）。糖尿病与中心性肥胖相互作用的归因比例为0.571（95% CI 0.017-1.125）。结论蒙古族人群中，糖尿病合并中心性肥胖者发生脑卒中的危险性显著高于糖尿病合并中心性肥胖者。这项研究表明，中心性肥胖和糖尿病协同作用，增加中风的风险。
BackgroundThe relationship between central obesity and stroke is inconsistent in diabetic and non-diabetic populations. This indicates an interaction between diabetes and central obesity on stroke risk. The present study aimed to examine the interaction in a cohort of Inner Mongolians.MethodsIn this prospective cohort study, we assessed the interaction between diabetes and central obesity on stroke incidence between June 2003 and July 2012. At baseline, 2,589 adults were recruited and examined from Inner Mongolia, China. Participants were categorized into four subgroups according to presence of diabetes and/or central obesity. Both additive and multiplicative interactions were evaluated using Cox proportional-hazard models.Results121 stroke events were recorded during the follow-up period. The cumulative incidence of stroke was highest for participants with both diabetes and central obesity (log-rank test,P= 0.042). The multivariable-adjusted risk for stroke was significantly higher in participants with both conditions (HR = 3.02, 95% CI 1.24-7.33,P =0.015) compared to those with neither diabetes nor central obesity. Attributable proportion due to the interaction between diabetes and central obesity was 0.571 (95% CI 0.017-1.125). The multiplicative interactive effect between diabetes and central obesity on stroke was also statistically significant (HR = 2.67, 95% CI 1.14-6.26,P= 0.024).ConclusionsThe participants who were both diabetic and centrally obese had significantly higher risk for incident stroke than the combination of individuals who individually had either condition among Mongolian population. This study suggests that central obesity and diabetes act synergistically to increase the risk of stroke.
登录
查看更多内容
影响因子：
2.6
作者：
Fahimfar N;Khalili D;Mohebi R;Azizi F;Hadaegh F
通讯作者：
Hadaegh F
糖尿病的医疗标准 - 2010年。
影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
影响因子：
158.5
作者：
Duckworth, William;Abraira, Carlos;Huang, Grant D.
通讯作者：
Huang, Grant D.
影响因子：
16.2
作者：
Ohnishi, H;Saitoh, S;Shimamoto, K
通讯作者：
Shimamoto, K
影响因子：
8.3
作者：
Giorda, Carlo Bruno;Avogaro, Angelo;Ferrannini, Ele
通讯作者：
Ferrannini, Ele