IGF1/IGF1R/STAT3 signaling-inducible IFITM2 promotes gastric cancer growth and metastasis
IGF1/IGF1R/STAT3 signaling-inducible IFITM2 promotes gastric cancer growth and metastasis
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IGF1/IGF1R/STAT3信号诱导的IFITM2促进胃癌生长和转移
DOI：
10.1016/j.canlet.2017.02.014
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发表时间：
2017-05-01
期刊：
影响因子：
9.7
通讯作者：
Liao, Wangjun
中科院分区：
文献类型：
--
作者：
Xu, Li;Zhou, Rui;Liao, Wangjun
干扰素诱导的跨膜蛋白（IFITM）在某些类型的癌症中表达。然而，它们在肿瘤进展中的确切作用仍不清楚。本研究探讨了IFITM 2在胃癌（GC）进展中的功能。对公共数据库和167例胃癌患者的回顾性分析显示，胃肿瘤样本中IFITM 2表达上调，与疾病进展、更频繁的术后复发和更高的死亡率正相关。IFITM 2敲低降低体外GC细胞增殖、迁移、侵袭和上皮向间质转化。我们还发现IFITM 2的表达部分是由胰岛素样生长因子（IGF）1通过IGF 1受体/信号转导和转录激活因子3信号传导诱导的。此外，IFITM 2调节白细胞介素-6的表达和分泌，从而增加IFITM 2的表达。IFITM 2表达沉默抑制体内肿瘤生长和肺转移。这些结果表明，IFITM 2是一种新的预后生物标志物和GC进展的调节剂。(C)2017爱思唯尔B. V.保留所有权利。
Interferon-induced transmembrane proteins (IFITMs) are expressed in some types of cancer. However, their precise roles in tumor progression remain unclear. The present study investigated the function of IFITM2 in gastric cancer (GC) progression. A retrospective analysis of a public database and 167 GC patients revealed that IFITM2 expression was upregulated in gastric tumor samples, which was positively correlated with disease progression, more frequent postoperative recurrence, and higher mortality rate. IFITM2 knockdown decreased GC cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition in vitro. We also found that IFITM2 expression was in part induced by insulin-like growth factor (IGF) 1 via IGF1 receptor/signal transducer and activator of transcription 3 signaling. Furthermore, IFITM2 regulated interleukin-6 expression and secretion, which in turn increased IFITM2 expression. Silencing of IFITM2 expression suppressed tumor growth and lung metastasis in vivo. These results suggest that IFITM2 is a novel prognostic biomarker and regulator of GC progression. (C) 2017 Elsevier B.V. All rights reserved.