Stability Enhancing N-Terminal PEGylation of Oxytocin Exploiting Different Polymer Architectures and Conjugation Approaches
Stability Enhancing N-Terminal PEGylation of Oxytocin Exploiting Different Polymer Architectures and Conjugation Approaches
复制标题
DOI：
10.1021/acs.biomac.6b00919
复制
发表时间：
2016-08-01
影响因子：
6.2
通讯作者：
Haddleton, David M.
中科院分区：
文献类型：
--
作者：
Collins, Jennifer;Kempe, Kristian;Haddleton, David M.
催产素是一种环状九氨基酸神经垂体激素治疗剂，可有效用于控制产后出血 (PPH)，并被列入世界卫生组织基本药物清单。然而，催产素在水溶液中的保质期稳定性有限，特别是在超过 25 摄氏度的温度下，并且注射水性催产素制剂需要冷藏（
Oxytocin, a cyclic nine amino acid neurohypophyseal hormone therapeutic, is effectively used in the control of postpartum hemorrhaging (PPH) and is on the WHO List of Essential Medicines. However, oxytocin has limited shelf life stability in aqueous solutions, particularly at temperatures in excess of 25 degrees C and injectable aqueous oxytocin formulations require refrigeration (