Levels of complement components iC3b, C3c, C4, and SC5b-9 in peritoneal fluid and serum of infertile women with endometriosis
Levels of complement components iC3b, C3c, C4, and SC5b-9 in peritoneal fluid and serum of infertile women with endometriosis
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DOI：
10.1016/j.fertnstert.2006.12.061
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发表时间：
2007-11-01
影响因子：
6.7
通讯作者：
Mielczarek-Palacz, Aleksandra
中科院分区：
文献类型：
--
作者：
Kabut, Jacek;Kondera-Anasz, Zdzislawa;Mielczarek-Palacz, Aleksandra
目的：评估补体成分 iC3b、C3c、C4 和 SC5b-9 是否可能参与子宫内膜异位症的发病机制。设计：前瞻性、实验性试验。地点：医科大学。患者：112 名接受腹腔镜检查的不孕妇女。干预措施：静脉穿刺和腹腔镜腹腔镜收集腹腔液。主要结果指标：腹腔液和血清采用酶联免疫吸附测定（ELISA）法测定iC3b、C3c、C4和SC5b-9水平。结果（S）：与腹腔液相比，血清中发现C3c、C4和SC5b-9补体成分的水平较高，但腹腔液中iC3b的水平较高。我们观察到，与健康女性相比，子宫内膜异位症女性的腹腔液和血清中 C3c、C4 和 SC5b-9 的浓度较高。然而，腹腔液和血清中iC3b的水平均显着低于对照组。结论（S）：补体系统激活调节机制的受损可能是子宫内膜异位症及子宫内膜异位症相关不孕症发病的重要因素。
Objective: To assess whether complement components iC3b, C3c, C4, and SC5b-9 may be involved in the pathogenesis of endometriosis.Design: Prospective, experimental trial.Setting: Medical university.Patient(s): 112 women infertile women undergoing laparoscopy.Intervention(s): Venipuncture and laparoscopic peritoneal fluid collection.Main Outcome Measure(s): Peritoneal fluid and serum iC3b, C3c, C4, and SC5b-9 levels were measured by enzyme-linked immunosorbent assay (ELISA) method.Result(S): Higher levels of C3c, C4, and SC5b-9 complement components were found in the serum compare wit the peritoneal fluid, but the levels of iC3b were higher in the peritoneal fluid. We observed higher concentrations of C3c, C4, and SC5b-9 in the peritoneal fluid and serum of women with endometriosis compared with healthy women. However, the levels of iC3b in both peritoneal fluid and serum were statistically significantly lower than in the control group.Conclusion(S): The impairment of the mechanisms involved in the regulation of activation of complement system may be an important factor in the pathogenesis of endometriosis and endometriosis-associated infertility.