Persistent infections support maintenance of a coronavirus in a population of Australian bats (Myotis macropus).
Persistent infections support maintenance of a coronavirus in a population of Australian bats (Myotis macropus).
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持续的感染支持维持澳大利亚蝙蝠（Myotis Macropus）的冠状病毒。
DOI：
10.1017/s0950268817000991
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发表时间：
2017-07
影响因子：
4.2
通讯作者：
McCallum H
中科院分区：
文献类型：
--
作者：
Jeong J;Smith CS;Peel AJ;Plowright RK;Kerlin DH;McBroom J;McCallum H
了解储存宿主群体内的病毒传播动态有助于更好地了解新出现的传染病的溢出效应。虽然蝙蝠传播的病毒引起公众健康的关注，但由于缺乏单个蝙蝠的纵向数据，对其动态的调查受到限制。在这里，我们在贝叶斯框架内检查了感染一种假定的新型 Alphacoronavirus 的澳大利亚蝙蝠（Myotis Macropus）的捕获-标记-再捕获 (CMR) 数据。然后，我们开发了流行病模型来估计持续感染个体（长时间传播病毒）对研究人群中病毒维持概率的影响。我们发现 CMR 数据分析支持将传染性蝙蝠分为持续性和暂时性传染性蝙蝠。与不分组蝙蝠的流行病模型相比，在包括持续性和暂时性感染性蝙蝠的流行病模型中，研究人群中冠状病毒的维持更有可能。这些发现利用来自蝙蝠个体纵向样本的罕见 CMR 数据，增加了我们对蝙蝠病毒传染病传播动力学的理解。
Understanding viral transmission dynamics within populations of reservoir hosts can facilitate greater knowledge of the spillover of emerging infectious diseases. While bat-borne viruses are of concern to public health, investigations into their dynamics have been limited by a lack of longitudinal data from individual bats. Here, we examine capture–mark–recapture (CMR) data from a species of Australian bat (Myotis macropus) infected with a putative novel Alphacoronavirus within a Bayesian framework. Then, we developed epidemic models to estimate the effect of persistently infectious individuals (which shed viruses for extensive periods) on the probability of viral maintenance within the study population. We found that the CMR data analysis supported grouping of infectious bats into persistently and transiently infectious bats. Maintenance of coronavirus within the study population was more likely in an epidemic model that included both persistently and transiently infectious bats, compared with the epidemic model with non-grouping of bats. These findings, using rare CMR data from longitudinal samples of individual bats, increase our understanding of transmission dynamics of bat viral infectious diseases.