Quantitative Analysis of Three Distinct Retinal Capillary Plexuses in Healthy Eyes Using Optical Coherence Tomography Angiography
Quantitative Analysis of Three Distinct Retinal Capillary Plexuses in Healthy Eyes Using Optical Coherence Tomography Angiography
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DOI：
10.1167/iovs.17-22036
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发表时间：
2017-10-01
影响因子：
4.4
通讯作者：
Sarraf, David
中科院分区：
文献类型：
--
作者：
Garrity, Sean T.;Iafe, Nicholas A.;Sarraf, David
目得：识别和量化的三个不同的视网膜毛细血管丛和中心凹无血管区（FAZ）在健康受试者根据年龄使用光学相干断层扫描血管造影术（OCTA）与新的投影伪影消除（PAR）软件和改进segmentation.METHODS：在这个横断面研究中的所有眼睛进行OCTA成像使用RTVue XR Avanti与新的PAR AngioVue软件。OCTA扫描分析和三个主要的旁视网膜毛细血管丛分割和血管密度和FAZ面积的计算。结果：共152正常眼95例（39名男性，56名女性，平均年龄42 +/- 25岁）。在3 x 3 mm OCTA图像中，浅层视网膜毛细血管丛（SCP）的平均血管密度为15.48 +/- 2.04 mm（-1），中层视网膜毛细血管丛（ICP）为15.28 +/- 1.82 mm（-1），深层视网膜毛细血管丛（DCP）为16.33 +/- 2.32 mm（-1）。3 x 3 mm扫描分析得出平均FAZ面积为0.270 +/- 0.101 mm 2。使用3 x 3 mm OCTA扫描时，SCP、ICP和DCP中血管密度的平均降低值分别为0.04 mm（-1）（0.22%）、0.05 mm（-1）（0.27%）和0.06 mm（-1）（0.30%）。FAZ面积每增加一岁平均增加0.0015 mm（2）（0.72%）。结论：新型PAR软件可以提供包括ICP在内的所有三个主要视网膜旁毛细血管丛的更好的可视化。使用该技术，SCP，ICP和DCP血管密度随着年龄的增长而下降，而FAZ面积随着年龄的增长而增加。
PURPOSE: To identify and quantify the three distinct retinal capillary plexuses and the foveal avascular zone (FAZ) in healthy subjects according to age using optical coherence tomography angiography (OCTA) with novel projection artifact removal (PAR) software and improved segmentation.METHODS: All eyes in this cross-sectional study underwent OCTA imaging using RTVue XR Avanti with novel PAR AngioVue software. OCTA scans were analyzed and the three main parafoveal retinal capillary plexuses were segmented and vessel density and FAZ area were calculated.RESULTS: A total of 152 normal eyes from 95 subjects (39 males, 56 females, mean age 42 +/- 25 years) were included. The mean vessel density was 15.48 +/- 2.04 mm(-1) in the superficial retinal capillary plexus (SCP), 15.28 +/- 1.82 mm(-1) in the intermediate retinal capillary plexus (ICP), and 16.33 +/- 2.32 mm(-1) in the deep retinal capillary plexus (DCP) for 3 x 3-mm OCTA images. Analysis of 3 x 3-mm scans yielded a mean FAZ area of 0.270 +/- 0.101 mm2. The average reduction in vessel density per year of age with 3 x 3-mm OCTA scans was 0.04 mm(-1) (0.22%) in the SCP, 0.05 mm(-1) (0.27%) in the ICP, and 0.06 mm(-1) (0.30%) in the DCP. The average increase in FAZ area per year of age was 0.0015 mm(2) (0.72%).CONCLUSIONS: Novel PAR software may provide improved visualization of all three major parafoveal retinal capillary plexuses including the ICP. Using this technology, SCP, ICP, and DCP vessel density decreased with increasing age while FAZ area increased with age.