Glomerular filtration rate in children with advanced chronic renal failure: methods of determination and clinical applications.
Glomerular filtration rate in children with advanced chronic renal failure: methods of determination and clinical applications.
复制标题
晚期慢性肾功能衰竭儿童的肾小球滤过率：测定方法和临床应用。
DOI：
--
复制
发表时间：
1982
影响因子：
4.2
通讯作者：
A. Sharpe
中科院分区：
文献类型：
--
作者：
J. Chan;A. Sharpe
综述了目前用于测定晚期慢性肾病儿童肾小球滤过率的方法的基本原理、意义和缺陷。显示了婴儿和儿童从出生到成年的正常肾脏清除率。评估了肾功能的连续测量方法，特别是通过血清肌酐浓度的倒数。它们在临床上用于监测保守治疗和新治疗方式的有效性，例如膳食补充必需氨基酸及其酮类似物，并确定 1,25-二羟基维生素-D3 治疗肾性骨营养不良不会加速慢性肾功能不全儿童肾功能的恶化。
The rationale, significance and pitfalls of currently available methods for the determination of glomerular filtration rates in children with advanced chronic renal diseases are reviewed. Normal renal clearances in infants and children from birth to adulthood are presented. Methods of serial measurements of renal function, especially by the reciprocals of serum creatinine concentrations, are evaluated. They are applied clinically to monitor the effectiveness of conservative and new modalities of treatment, such as dietary supplementation with essential amino acids plus their keto analogues, and to determine that 1,25-dihydroxyvitamin-D3 treatment of renal osteodystrophy does not accelerate the deterioration of renal function in children with chronic renal insufficiency.