[Effect of HMME-PDT on hyperplastic scar in rabbit ear model].
[Effect of HMME-PDT on hyperplastic scar in rabbit ear model].
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发表时间：
2007-09
期刊：
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通讯作者：
H. Cai;Y. Gu;J. Zeng;Shao-ran Li;Ying Wang;Dongye Shi;Lu-yong Zhang
中科院分区：
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作者：
H. Cai;Y. Gu;J. Zeng;Shao-ran Li;Ying Wang;Dongye Shi;Lu-yong Zhang
目的探讨HMME-PDT（血卟啉单甲醚光动力疗法）对兔耳增生性疤痕的治疗效果。方法建立兔耳真皮增生性疤痕急性模型。 24个疤痕被随机分为2组：实验组（n = 12）接受HMME-PDT治疗，对照组（n = 12）不接受特殊治疗。术后第28天从疤痕处采集标本。分别采用苏木精-伊红染色和Van-Gieson染色观察疤痕增生情况和胶原纤维情况。在显微镜下计算微血管密度。结果与对照组相比，实验组HMME-PDT治疗减少了疤痕形成，降低了微血管密度，防止了伤口部位胶原蛋白过度沉积。结论 HMME-PDT可能具有抑制兔耳增生性疤痕的作用。
OBJECTIVE To investigate the effect of HMME-PDT (Hematoporphyrin Monomethyl Ether-Photodynamic therapy) on Hyperplastic scar in the rabbit ear. METHODS The acute model of dermal Hyperplastic scar in the rabbit ear was established. 24 scars were randomly divided into 2 groups: the experimental group (n = 12) received HMME-PDT treatment, and the controlled group (n = 12) received no special treatment. Specimens were harvested from scars on postoperative 28 day. Scar hyper plasty and collagen fibers were observed by haematoxylin-eosin staining and Van-Gieson staining respectively. The microvessel density was calculated under microscope. RESULTS Compared with the controlled group, HMME-PDT treatment in the experimental group reduced scar formation, decreased the microvessel density and prevented excess collagen deposition at the wound site. CONCLUSIONS HMME-PDT may play a role in inhibiting hyperplastic scar in rabbit ear.