CD5L contributes to the pathogenesis of methicillin-resistant Staphylococcus aureus-induced pneumonia
CD5L contributes to the pathogenesis of methicillin-resistant Staphylococcus aureus-induced pneumonia
复制标题
CD5L参与耐甲氧西林金黄色葡萄球菌引起的肺炎的发病机制
DOI：
10.1016/j.intimp.2019.03.057
复制
发表时间：
2019-07-01
影响因子：
5.6
通讯作者：
Cao, Ju
中科院分区：
文献类型：
--
作者：
Gao, Xun;Yan, Xingxing;Cao, Ju
金黄色葡萄球菌是社区和医疗保健获得性肺炎的主要病原菌。CD5L是控制免疫动态平衡的重要蛋白质。在本研究中，我们发现金黄色葡萄球菌肺炎患者的循环CD5L水平升高。同样，金黄色葡萄球菌肺炎小鼠肺部CD5L水平升高。抗CD5L抗体对耐甲氧西林金黄色葡萄球菌致死性肺炎有保护作用。抗CD5L抗体的存活受益与细菌清除的改善和肺炎性细胞因子和趋化因子的减少有关。相反，重组CD5L和金黄色葡萄球菌联合注射可显著增加金黄色葡萄球菌肺炎的致死率。提示CD5L参与了金黄色葡萄球菌肺炎的免疫病理过程。
Staphylococcus aureus is a major causative microorganism in community- and healthcare-acquired pneumonia. CD5L is an important protein in the control of immune homeostasis. In this study, we found that patients with S. aureus pneumonia displayed increased levels of circulating CD5L. Likewise, mice with S. aureus pneumonia had elevated CD5L levels in the lungs. Anti-CD5L antibody protected mice from lethal pneumonia induced by methicillin-resistant S. aureus. The survival benefit obtained with antibody against CD5L was associated with an improvement of bacterial clearance and a reduction of pulmonary inflammatory cytokines and chemokines. Conversely, co-injection of recombinant CD5L and S. aureus markedly increased the lethality of S. aureus pneumonia. These findings suggest that CD5L contributed to the immunopathology of S. aureus pneumonia.