STUDIES ON DNA-REPLICATION IN THE BACTERIOPHAGE-T4 INVITRO SYSTEM
STUDIES ON DNA-REPLICATION IN THE BACTERIOPHAGE-T4 INVITRO SYSTEM
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DOI：
10.1101/sqb.1983.047.01.077
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
KREUZER, KN
中科院分区：
文献类型：
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作者：
ALBERTS, BM;BARRY, J;KREUZER, KN
从DNA复制装置的纯化组分重构的体外系统为我们提供了关于DNA复制的机制方面的许多知识。大型DNA噬菌体特别适合这种方法，因为它们编码自身复制所需的大多数蛋白质。这使得定义基本复制基因并分离其产物的任务比细菌或真核细胞中的任务更加简单。
In vitro systems reconstituted from the purified components of a DNA replication apparatus have provided us with much of our knowledge about the mechanistic aspects of DNA replication. The large DNA bacteriophages are especially suited for this approach, since they code for most of the proteins required for their own replication. This makes the task of defining essential replication genes and isolating their products much more straightforward than in bacteria or eukaryotic cells.