Does Hemodialysis Hurt the Brain?
Does Hemodialysis Hurt the Brain?
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DOI：
10.1111/j.1525-139x.2011.00857.x
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发表时间：
2011-05-01
影响因子：
1.6
通讯作者：
Sarnak, Mark J.
中科院分区：
文献类型：
--
作者：
Madero, Magdalena;Sarnak, Mark J.
透析患者的大脑结构异常和认知障碍的患病率很高。然而，脑结构异常和认知障碍的发病机制以及两者之间的关系尚不清楚。在这篇社论中，我们质疑血液透析过程本身是否可能部分导致影像学研究中发现的结构异常以及认知障碍。我们援引了几种机制，其中程序本身可能会“伤害”大脑，包括血压的快速变化，微栓塞，微出血和脑水肿。然后，我们总结了研究问题，其答案可能有助于推动该领域的发展。
Dialysis patients have a high prevalence of both structural brain abnormalities and cognitive impairment. The pathogenesis of the structural brain abnormalities and cognitive impairment as well the relationship between the two is however less clear. In this editorial, we question whether the hemodialysis procedure itself may be partly responsible for the structural abnormalities noted on imaging studies as well as for the cognitive impairment. We invoke several mechanisms whereby the procedure itself may "hurt" the brain including rapid changes in blood pressure, microembolization, microbleeds, and cerebral edema. We then summarize research questions whose answers may help move the field forward.