Computational models of hair cell bundle mechanics: II. Simplified bundle models
Computational models of hair cell bundle mechanics: II. Simplified bundle models
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DOI：
10.1016/j.heares.2004.06.005
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发表时间：
2004-11-01
期刊：
影响因子：
2.8
通讯作者：
Grant, W
中科院分区：
文献类型：
--
作者：
Cotton, J;Grant, W
简化版本的毛细胞束的机械建模。束刚度，链接张力和变形形状的各种几何和材料组合的影响进行检查;三个模型进行了分析，在本文中：两个静纤毛连接一个链接，两个静纤毛连接的一组生物现实的链接，和一列的静纤毛连接的现实链接。使用分布参数模型[J.Biomech.Eng. 122，44]对静纤毛进行建模。从这些试验中得出了连接束的一些基本规则：（1）连接必须具有使束作为整体变形的阈值刚度值。超过这个值，静纤毛是完美的链接和链接刚度的变化不会显着影响束刚度或链接张力。(2)降低连续静纤毛的相对高度可以增加连接张力，同时降低束刚度。(3)当横向链接存在时，最顶部的横向链接承载大部分张力。单柱模型中的下部连接件在机械上似乎不重要。(4)一旦柱达到一定长度，延长柱中束的长度不会增加刚度。(C)2004 Elsevier B. V.保留所有权利。
Simplified versions of hair cell bundles are mechanically modeled. The influence of various geometric and material combinations on bundle stiffness, link tensions and deformation shape are examined; Three models are analyzed within this paper: two stereocilia connected by one link, two stereocilia connected by a biologically realistic set of links, and a column of stereocilia connected by realistic links. Stereocilia are modeled using a distributed parameter model [J.Biomech.Eng. 122, 44]. Some fundamental rules for linking bundles emerge from these tests: (1) Links must have a threshold stiffness value for the bundle to deform as a whole. Beyond this value, the stereocilia are perfectly linked and variations in link stiffness do not significantly effect the bundle stiffness or link tension. (2) Decreasing the relative heights of successive stereocilia may increase link tension while decreasing bundle stiffness. (3) When lateral links exist, the top most lateral links carry the majority of tension. Lower links in single column model appear mechanically insignificant. (4) Extending the length of the bundle in a column does not increase the stiffness once the column reaches a certain length. (C) 2004 Elsevier B.V. All rights reserved.