Optimizing Adherence to Preexposure and Postexposure Prophylaxis: The Need for an Integrated Biobehavioral Approach
Optimizing Adherence to Preexposure and Postexposure Prophylaxis: The Need for an Integrated Biobehavioral Approach
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DOI：
10.1093/cid/civ111
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发表时间：
2015-06-01
影响因子：
11.8
通讯作者：
Safren, Steven A.
中科院分区：
文献类型：
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作者：
Blashill, Aaron J.;Ehlinger, Peter P.;Safren, Steven A.
暴露前预防（PrEP）和暴露后预防（PEP）已被证明可有效预防人类免疫缺陷病毒（HIV）的传播。目前的PrEP文献中说明了依从性和HIV传播之间的剂量反应关系，PrEP的依从性干预可能是有用的，尽管目前已经开发和测试了一些有效的方案。有一个随机对照试验测试PEP依从性干预的缺乏，需要进一步的研究。最后，我们提出了定制依从性咨询以解决可能对依从性产生负面影响的心理社会因素和心理健康压力源的重要性。
Preexposure prophylaxis (PrEP) and postexposure prophylaxis (PEP) has been shown to be effective in preventing transmission of human immunodeficiency virus (HIV). A dose-response relationship between adherence and HIV transmission is illustrated in the current PrEP literature, and adherence interventions for PrEP may be useful, although currently few effective programs have been developed and tested. There is a paucity of randomized controlled trials testing PEP adherence interventions, and further research is needed. We conclude by proposing the importance of tailoring adherence counseling to address psychosocial factors and mental health stressors that may negatively affect adherence.