Protein degradation during aging: the lysosome-, the calpain- and the proteasome-dependent cellular proteolytic systems
Protein degradation during aging: the lysosome-, the calpain- and the proteasome-dependent cellular proteolytic systems
复制标题
DOI：
10.1023/a:1015236203379
复制
发表时间：
2002-01-01
期刊：
影响因子：
4.5
通讯作者：
Gonos, ES
中科院分区：
文献类型：
--
作者：
Chondrogianni, N;Fragoulis, EG;Gonos, ES
衰老是由遗传和环境因素共同决定的自然过程。衰老伴随着几种细胞稳态机制的功能失衡，这导致异常（即氧化，交联，未折叠）蛋白质的积累。已经提出，在衰老过程中增加的稳态失败是由于由溶酶体、钙蛋白酶和蛋白酶体介导的主要细胞蛋白水解机制的功能受损。本文将讨论这些细胞蛋白水解系统在衰老过程中的功能问题。
Aging is a natural process determined by both genetic and environmental factors. Aging is accompanied by the imbalance of the function of several cellular homeostatic mechanisms, which results, among others, in the accumulation of abnormal (i.e. oxidized, cross-linked, unfolded) proteins. It has been proposed that the increased failure of homeostasis during aging is due to the impaired function of the major cellular proteolytic mechanisms mediated by the lysosome, the calpains and the proteasome. This article will address the issue of the function of these cellular proteolytic systems during aging.