The Complex and Diversified Mitochondrial Gene Pool of Berber Populations
The Complex and Diversified Mitochondrial Gene Pool of Berber Populations
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DOI：
10.1111/j.1469-1809.2008.00493.x
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发表时间：
2009-03-01
影响因子：
1.9
通讯作者：
Dugoujon, J. M.
中科院分区：
文献类型：
--
作者：
Coudray, C.;Olivieri, A.;Dugoujon, J. M.
通过对部分控制区（包括HVS-I和HVS-II的一部分）测序和调查单倍型群特异性编码区标记，对来自摩洛哥（Asni，Bouhria和Figuig）和埃及锡瓦绿洲的295名柏柏尔人的线粒体DNA变异进行了评估。我们的研究结果表明，柏柏尔人线粒体池的特点是由一个整体的高频率的西欧单倍群，某种程度上较低的频率撒哈拉以南的L谱系，和一个显着的（但差异）存在的北非单倍群U6和M1，从而占据了欧洲和撒哈拉以南的人口之间的PCA分析的中间位置。马格里布柏柏尔人和埃及柏柏尔人之间也有明显的遗传分化。第一个与欧洲人群有关，如单倍型群H1和V频率所示，而后者与东非和尼罗河谷人群有更多的亲缘关系，如M1的高频率和L0 a1，L3 i，L4* 和L4 b2谱系的存在所示。此外，在锡瓦没有观察到单倍群U6。我们的结论是，柏柏尔人的起源和母亲的多样性是古老而复杂的，这些社区承担的基因流与周围和迁移人口的各种事件产生的遗传特征。
The mitochondrial DNA variation of 295 Berber-speakers from Morocco (Asni, Bouhria and Figuig) and the Egyptian oasis of Siwa was evaluated by sequencing a portion of the control region (including HVS-I and part of HVS-II) and surveying haplogroup-specific coding region markers. Our findings show that the Berber mitochondrial pool is characterized by an overall high frequency of Western Eurasian haplogroups, a somehow lower frequency of sub-Saharan L lineages, and a significant (but differential) presence of North African haplogroups U6 and M1, thus occupying an intermediate position between European and sub-Saharan populations in PCA analysis. A clear and significant genetic differentiation between the Berbers from Maghreb and Egyptian Berbers was also observed. The first are related to European populations as shown by haplogroup H1 and V frequencies, whereas the latter share more affinities with East African and Nile Valley populations as indicated by the high frequency of M1 and the presence of L0a1, L3i, L4*, and L4b2 lineages. Moreover, haplogroup U6 was not observed in Siwa. We conclude that the origins and maternal diversity of Berber populations are old and complex, and these communities bear genetic characteristics resulting from various events of gene flow with surrounding and migrating populations.