Atopic dermatitis as a systemic disease
Atopic dermatitis as a systemic disease
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DOI：
10.1016/j.clindermatol.2013.11.007
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发表时间：
2014-05-01
影响因子：
2.7
通讯作者：
Ruhr, Joachim W.
中科院分区：
文献类型：
--
作者：
Darlenski, Razvigor;Kazandjieva, Jana;Ruhr, Joachim W.
特应性皮炎（AD）是一种严重影响患者生活质量的慢性炎症性疾病。免疫偏离和表皮屏障缺陷被定义为疾病发展的病理生理机制。特应性进展，或从婴儿期特应性皮炎到哮喘和变应性鼻炎的自然进展，是多器官参与特应性的经典例子。据推测，表皮屏障损伤是导致特应性进展的主要病理条件。近几十年来，越来越多的证据表明AD可伴有多种全身性疾病，例如自身免疫性疾病、眼科受累、嗜酸性胃肠炎、炎症性肠道疾病、肾病综合征和代谢性疾病。这篇文章回顾了这些关联，并重点讨论了AD及其相关综合征可能的共同潜在机制。我们提出AD是一种多器官系统性疾病的概念。(C)2014 Elsevier Inc. All rights reserved.
Atopic dermatitis (AD) is a chronic inflammatory disease that seriously affects the quality of life of these patients. Both immune deviations and epidermal barrier deficiency have been defined as pathophysiologic mechanisms in the disease development The atopic march, or the natural progression form atopic dermatitis in infancy to asthma and allergic rhinitis, is a classic example for the multiorgan involvement in atopy. It has been hypothesized that epidermal barrier impairment is the primary pathologic condition responsible for the atopic march. In recent decades, a growing body of evidence has accumulated that AD can be accompanied by a variety of systemic diseases, such as autoimmune disorders, ophthalmologic involvement, eosinophilic gastroenteritis, inflammatory bowel disease, nephritic syndrome, and metabolic diseases. This contribution reviews these associations and focuses on the possible common underlying mechanisms of AD and the associated syndromes. We present a concept on AD as a multiorgan systemic disease. (C) 2014 Elsevier Inc. All rights reserved.