Zebrafish heart regeneration: 15 years of discoveries.
Zebrafish heart regeneration: 15 years of discoveries.
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DOI：
10.1002/reg2.83
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Burns CG
中科院分区：
文献类型：
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作者：
González-Rosa JM;Burns CE;Burns CG
心血管疾病是全世界死亡的主要原因。与肝脏等其他器官相比，成年人的心脏在受伤后缺乏宏观再生的能力。因此，心肌梗塞约占所有心血管相关死亡的一半。相比之下，斑马鱼心脏在受伤后可以通过强劲的心肌增殖有效地再生。因此，破译斑马鱼心脏内源性再生能力的机制为确定诱导人类心脏再生的新治疗策略提供了一条令人兴奋的途径。这篇综述提供了成年斑马鱼心脏再生的历史概述。我们总结了 15 年的研究，特别关注这个迷人领域的最新发展。我们讨论解决再生研究基本问题的实验结果。再生肌肉的起源是什么？从遗传和分子角度来看，再生是如何控制的？不同的细胞类型如何相互作用以实现器官再生？了解心脏再生的自然模型将使我们更接近回答终极问题：我们如何刺激人类心肌再生？
Cardiovascular disease is the leading cause of death worldwide. Compared to other organs such as the liver, the adult human heart lacks the capacity to regenerate on a macroscopic scale after injury. As a result, myocardial infarctions are responsible for approximately half of all cardiovascular related deaths. In contrast, the zebrafish heart regenerates efficiently upon injury through robust myocardial proliferation. Therefore, deciphering the mechanisms that underlie the zebrafish heart's endogenous regenerative capacity represents an exciting avenue to identify novel therapeutic strategies for inducing regeneration of the human heart. This review provides a historical overview of adult zebrafish heart regeneration. We summarize 15 years of research, with a special focus on recent developments from this fascinating field. We discuss experimental findings that address fundamental questions of regeneration research. What is the origin of regenerated muscle? How is regeneration controlled from a genetic and molecular perspective? How do different cell types interact to achieve organ regeneration? Understanding natural models of heart regeneration will bring us closer to answering the ultimate question: how can we stimulate myocardial regeneration in humans?