The role of limbic vasopressin and oxytocin in social recognition
The role of limbic vasopressin and oxytocin in social recognition
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DOI：
10.1016/0006-8993(95)01505-1
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发表时间：
1996-03-25
期刊：
影响因子：
2.9
通讯作者：
Maigret, C
中科院分区：
文献类型：
--
作者：
Greidanus, TBV;Maigret, C
青年雄性大鼠两次染毒5min，老年雄性大鼠每隔30min染毒一次，抗催产素血清实验每隔120min染毒一次。在两次相遇期间，对年龄较大的大鼠进行社会调查所花费的时间进行评分。在接受安慰剂治疗的动物中，在30分钟的第二次相遇中花在年轻动物的社会调查上的时间比第一次(社会认可)要短得多。然而，脑室内或局部应用抗加压素血清在背侧或腹侧海马区或背侧隔区，但不在嗅觉核，导致在两次相遇期间花费相似的时间进行社会调查。因此，背侧和腹侧海马区以及背侧隔区的内源性加压素在社会识别/记忆中起着生理作用。在接受安慰剂治疗的大鼠中，在120分钟的第二次相遇中，花在年轻动物的社会调查上的时间与第一次相遇时相似。然而，在腹侧海马区局部注射抗催产素血清，而不是在背侧海马区，也不在嗅核或隔区局部注射催产素血清，可以缩短第二次相遇期间的调查时间。因此，在腹侧海马区存在或局部释放加压素和催产素，以及在背侧海马区和背侧隔区存在或局部释放加压素(但不释放催产素)对社会识别具有重要的生理意义。
Young male rats were exposed two times for 5 min, to older male rats with an interval of 30 min in the anti-vasopressin serum experiments and with an interval of 120 min in the anti-oxytocin serum experiments. The time spent by the older rats with social investigation of the younger animal was scored during the two encounters. In placebo-treated animals the time spent on social investigation of the younger animal during the second encounter at 30 min is significantly shorter than during the first one (social recognition). However, intracerebroventricular or local application of anti-vasopressin serum in the dorsal or ventral hippocampus or in the dorsal septal area, but not in the n. olfactorius, results in similar periods of time spent for social investigation during the two encounters. Thus, endogenous vasopressin in the dorsal and ventral hippocampus and in the dorsal septal region plays a physiological role in social recognition/memory. In placebo-treated rats the time spent on social investigation of the younger animal during the second encounter at 120 min is similar to that during the first encounter. However, local administration of anti-oxytocin serum in the ventral hippocampus, but not in the dorsal hippocampus, nor in the n. olfactorius or the septal area, results in shorter investigation times during the second encounter. Thus, taken together the presence or local release of vasopressin and oxytocin in the ventral hippocampus and that of vasopressin (but not oxytocin) in the dorsal hippocampus and dorsal septal area are of physiological importance for social recognition.