Effect of green tea extract on obese women: A randomized, double-blind, placebo-controlled clinical trial
Effect of green tea extract on obese women: A randomized, double-blind, placebo-controlled clinical trial
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DOI：
10.1016/j.clnu.2008.03.007
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发表时间：
2008-06-01
影响因子：
6.3
通讯作者：
Chou, Pesus
中科院分区：
文献类型：
--
作者：
Hsu, Chung-Hua;Tsai, Tung-Hu;Chou, Pesus
目的：研究绿茶提取物（GTE）对肥胖女性的影响，并探讨其与肥胖相关激素肽的关系。方法：2006年7月~ 2007年6月在台湾台北医院进行随机、双盲、安慰剂对照临床试验。100名年龄在16至60岁之间、体重指数bbb27 kg/m(2)、在过去3个月内未接受任何其他体重控制方法的肥胖女性中，有78人完成了这项研究。随机分为A组和B组。A组41例服用GTE白；B组37例服用纤维素作为安慰剂，每日3次，每次1粒（400 mg），连续12周。在研究开始时和GTE治疗12周后测量体重（BW）、体重指数（BMI）和腰围（WC）。将数据进行比较，并以减少百分比表示。结果：GTE治疗12周后，体重仅减少0.3% （0.15 kg）。没有统计数据。GTE组和安慰剂组在体重、体重指数和体重减少百分比上的差异。组内比较显示，GTE组低密度脂蛋白胆固醇和甘油三酯显著降低，高密度脂蛋白胆固醇、脂联素和胃饥饿素水平显著升高。另一方面，安慰剂组仅显示甘油三酯显著降低，而胃促生长素水平显著增加。结论：本研究显示GTE组和安慰剂组在治疗12周后BW、BMI和WC的降低百分比无统计学差异。研究结果表明，连续12周摄入GTE（491毫克儿茶素含有302毫克EGCG）是安全的。(C) 2008爱思唯尔有限公司和欧洲临床营养与代谢学会。版权所有。
Aims: To examine the effect of green tea extract (GTE) on obese women and to explore the relationship between GTE and obesity-related hormone peptides.Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted from July 2006 to June 2007 in Taipei Hospital, Taiwan. Seventy-eight of 100 obese women aged between 16 and 60 years with BMI > 27 kg/m(2) and who had not received any other weight control maneuvers within the last 3 months completed this study. The subjects were randomly divided into Groups A and B. Group A (n = 41) received GTE white Group B (n = 37) took cellulose as a placebo, one capsule (400 mg) three times each day for 12 weeks. The body weight (BW), body mass index (BMI) and waist circumflex (WC) were measured at the beginning of the study and after 12 weeks of treatment with GTE. The data were compared and expressed as % reduction.Results: There was only a 0.3% reduction in BW (0.15 kg) after 12 weeks of treatment with GTE. There was no statistical. difference in % reduction in BW, BMI and WC between the GTE and placebo groups. Within group comparison revealed that the GTE group had significant reduction in LDL-cholesterol and triglyceride, and marked increase in the level of HDL-cholesterol, adiponectin and ghrelin. On the other hand, the placebo group showed significant reduction in triglyceride only, and a marked increase in the level of ghrelin atone.Conclusions: This study showed no statistical difference in % reduction in BW, BMI and WC between the GTE and placebo groups after 12 weeks of treatment. The intake of GTE (491 mg catechins containing 302 mg EGCG) for 12 weeks is considered safe as shown by the results. (C) 2008 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.