Do comorbidity influences acute toxicity and outcome in elderly patients with endometrial cancer treated by adjuvant radiotherapy plus brachytherapy?
Do comorbidity influences acute toxicity and outcome in elderly patients with endometrial cancer treated by adjuvant radiotherapy plus brachytherapy?
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DOI：
10.1007/s12094-012-0986-9
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发表时间：
2013-08-01
影响因子：
3.4
通讯作者：
Fusco, V.
中科院分区：
文献类型：
--
作者：
Fiorentino, A.;Chiumento, C.;Fusco, V.
为探讨老年子宫内膜癌（EC）患者行辅助外照射放疗（EBRT）联合高剂量率近距离放射治疗（HDR-BRT）后的并发症与急性放射毒性的关系，采用ACE-27和Charlson并发症指数（CCI）对65岁以上的子宫内膜癌患者进行治疗后并发症评估。EBRT总剂量为45-50.4戈伊（1.8戈伊/天）。采用高剂量率快速放射治疗（HDR-BRT），阴道穹窿加强剂量2/3次，总剂量10-15戈伊。18例（51.43%）无ACE-27合并症，27例（77.14%）CCI <3.治疗期间，急性毒性轻微，不受合并症评分的影响。2年无进展生存率和总生存率分别为69%和80%。ACE-27和CCI不影响无进展生存期（p = 0.51，p = 0.3）和OS（p = 0.26，p = 0.5）。体外放射治疗加BRT-HDR在具有良好体力状态和低合并症的老年EC中耐受良好。
To correlate comorbidity and acute radiation toxicity in elderly patients treated with adjuvant external beam radiotherapy (EBRT) plus brachytherapy-high dose rate (HDR-BRT) for endometrial cancer (EC).Endometrial cancer patients over 65 were treated and evaluated for comorbidity assessment with ACE-27 and Charlson comorbidity index (CCI). EBRT total dose was 45-50.4 Gy (1.8 Gy/day). The vault vagina boost of dose was performed by HDR-BRT with 2/3 fractions with a total dose of 10-15 Gy.From 2008 to 2011, 35 patients were analyzed. Eighteen patients (51.43 %) had not ACE-27 comorbidity; while 27 patients (77.14 %) had CCI lower than three. During treatment, acute toxicity was mild and not influenced by the comorbidity score. Two-year Progression Free and Overall Survival were 69 and 80 %. ACE-27 and CCI did not affect progression-free survival (p = 0.51, p = 0.3) and OS (p = 0.26, p = 0.5).External beam radiotherapy plus BRT-HDR are well tolerated in EC elderly with good performance status and low comorbidity profile.