Apoptotic cell death in neuroblastoma.
Apoptotic cell death in neuroblastoma.
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DOI：
10.3390/cells2020432
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发表时间：
2013-06-20
期刊：
影响因子：
6
通讯作者：
Nakagawara A
中科院分区：
文献类型：
--
作者：
Li Y;Nakagawara A
神经母细胞瘤（Neuroblastoma，NB）是儿童最常见的恶性实体瘤之一，起源于神经嵴交感肾上腺系，具有高度异质性的生物学和临床行为。婴儿患者即使患有转移性疾病也经常发生自发消退，而患有播散性疾病的一岁以上患者尽管进行了强化的多模式治疗，但结局仍不佳。已经提出有利NB中的自发消退是由肿瘤中的神经生长因子（NGF）缺乏触发的，具有存活的NGF依赖性，而侵袭性NB具有缺陷的凋亡机制，其使得肿瘤细胞能够逃避凋亡并赋予对治疗的抗性。本文综述了最近发现的参与NB细胞凋亡的分子和途径，并讨论了它们对开发更有效的治疗策略的潜在前景。
Neuroblastoma (NB) is one of the most common malignant solid tumors in childhood, which derives from the sympathoadrenal lineage of the neural crest and exhibits extremely heterogeneous biological and clinical behaviors. The infant patients frequently undergo spontaneous regression even with metastatic disease, whereas the patients of more than one year of age who suffer from disseminated disease have a poor outcome despite intensive multimodal treatment. Spontaneous regression in favorable NBs has been proposed to be triggered by nerve growth factor (NGF) deficiency in the tumor with NGF dependency for survival, while aggressive NBs have defective apoptotic machinery which enables the tumor cells to evade apoptosis and confers the resistance to treatment. This paper reviews the molecules and pathways that have been recently identified to be involved in apoptotic cell death in NB and discusses their potential prospects for developing more effective therapeutic strategies against aggressive NB.