Risk of cancer in persons with AIDS in Italy, 1985-1998
Risk of cancer in persons with AIDS in Italy, 1985-1998
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DOI：
10.1038/sj.bjc.6601017
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发表时间：
2003-07-07
影响因子：
8.8
通讯作者：
Rezza, G
中科院分区：
文献类型：
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作者：
Del Maso, L;Franceschi, S;Rezza, G
意大利艾滋病登记处和覆盖23%意大利人口的19个癌症登记处(CRS)之间进行了创纪录的联系，以根据各种特征估计意大利艾滋病毒或艾滋病感染者(PWHA)的总体癌症负担。在12 104名年龄在15-69岁的威尔斯亲王医院中，对观察和预期的癌症数量和标准化发病率(SIRS)进行了评估，总计60421人年。卡波西肉瘤(KS，是一般人群的1749倍)、非霍奇金淋巴瘤(NHL，352例)和浸润性宫颈癌(22例)的SIR显著增加。此外，肛门癌(34例)、肺癌(2.4例)、脑肿瘤(4.4例)、何杰金氏病(16例)和白血病(5.3例)的SIR也显著升高。大多数肺癌和脑癌未经组织学证实，不排除与KS或NHL误分的可能性。所有非艾滋病定义癌症的SIR在男性为2.2，在女性为2.5。静脉注射吸毒者患肺癌(9.4)和脑肿瘤(6.7)的SIR显著高于其他传播类型(SIR分别为1.4和2.3)。这项研究证实了PWHA中NHL以外的血液淋巴系统肿瘤的SIRS增加，尽管比NHL小许多倍。与人类乳头瘤病毒相关的癌症的关联也被证实。
A record linkage was carried out between the Italian Registry of AIDS and 19 Cancer Registries (CRs), which covered 23% of the Italian population, to estimate the overall cancer burden among persons with HIV or AIDS (PWHA) in Italy, according to various characteristics. Observed and expected numbers of cancer and standardised incidence ratios (SIRs) were assessed until 1998 in 12 104 PWHA aged 15-69 years, for a total of 60 421 person-years. Significantly increased SIRs were observed for Kaposi's sarcoma (KS, 1749-fold higher than the general population), non-Hodgkin's lymphomas (NHL, 352), and invasive cervical cancer (22). SIR was significantly elevated also for cancer of the anus (34), lung cancer (2.4), brain tumours (4.4), Hodgkin's disease (16), and leukaemias (5.3). The majority of lung and brain cancers were not histologically confirmed, and the possibility of misclassification with KS or NHL cannot be ruled out. The SIR for all non-AIDS-defining cancers was 2.2 in men and 2.5 in women. Intravenous drug users showed significantly more elevated SIRs for lung cancer (9.4), and brain tumours (6.7) than other transmission categories (SIR = 1.4 and 2.3, respectively). This study confirmed increased SIRs for haemolymphopoietic neoplasms other than NHL in PWHA, although many-fold smaller than for NHL. An association with human papillomavirus-related cancers was also confirmed.