Report from a randomized control trial: improved alignment between circadian biology and sleep-wake behavior as a mechanism of depression symptom improvement in evening-type adolescents with depressive symptoms.
Report from a randomized control trial: improved alignment between circadian biology and sleep-wake behavior as a mechanism of depression symptom improvement in evening-type adolescents with depressive symptoms.
复制标题
一项随机对照试验的报告：改善昼夜节律生物学和睡眠-觉醒行为之间的一致性，作为改善患有抑郁症状的夜间型青少年抑郁症状的机制。
DOI：
10.1111/jcpp.13880
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Harvey,AllisonG
中科院分区：
文献类型：
--
作者：
Asarnow,LaurenD;Soehner,Adriane;Dolsen,Emily;Dong,Lulu;Harvey,AllisonG
研究目标 昼夜节律偏好在青少年中很常见。其特点是行为偏好较晚的睡眠和起床时间，并且与较高的重度抑郁症 (MDD) 发病率相关。本研究旨在 (a) 在具有夜间昼夜节律偏好和临床显着抑郁症状的青少年样本中测试认知行为睡眠干预（跨诊断睡眠和昼夜节律干预；TranS-C）的有效性，以及 (b) 评估昼夜节律生物学和睡眠-觉醒行为之间改善的一致性，作为睡眠和抑郁症状改善之间关系的潜在机制。方法具有夜间昼夜节律偏好和临床显着抑郁症状的青少年被随机分配接受TranS-C (n= 24) 或心理教育状况 (PE;n= 18)。使用客观的生物测量来测量昼夜节律生物学和睡眠-觉醒行为之间的一致性。在治疗前和治疗后进行睡眠和昼夜节律测量，并在治疗前和治疗后以及 6 个月和 12 个月的随访中测量抑郁症状。结果混合效应模型显示，与主动对照条件相比，TranS-C 在 12 个月的随访中导致 MDD 严重程度显着降低。麦克阿瑟中介分析旨在探索昼夜节律生物学和睡眠-觉醒行为之间的一致性，通过 12 个月的随访，作为降低抑郁症严重程度的中介，揭示了昼夜节律生物学与睡眠-觉醒行为之间的一致性变化与治疗组之间存在显着的相互作用，表明治疗后昼夜节律生物学与睡眠-觉醒行为之间一致性的改善与治疗条件下 12 个月随访时抑郁症结果的改善相关。结论这些结果为改善昼夜节律生物学之间的一致性提供了新的证据睡眠-觉醒行为作为抑郁症改善的一种具体机制，为睡眠与抑郁症之间的复杂关系提供了关键线索，并对患有抑郁症的青少年具有重要的临床意义。
Study objectivesAn evening circadian preference is common among adolescents. It is characterized by a behavioral predilection for later sleep and wake timing and is associated with higher rates of Major Depressive Disorder (MDD). The present study aims to (a) test the effectiveness of a cognitive behavioral sleep intervention (Transdiagnostic Sleep and Circadian Intervention; TranS‐C) in a sample of adolescents with an evening circadian preference and clinically significant depressive symptoms and (b) evaluate improved alignment between circadian biology and sleep–wake behavior as a potential mechanism in the relationship between sleep and depression symptom improvement.MethodsAdolescents with an evening circadian preference and clinically significant depressive symptoms were randomized to receive TranS‐C (n= 24) or a psychoeducation condition (PE;n= 18). Alignment between circadian biology and sleep–wake behavior was measured using objective biological measurement. Measures of sleep and circadian rhythm were taken at pre‐ and posttreatment, and depression symptoms were measured at pre‐ and posttreatment and 6‐ and 12‐month follow‐up.ResultsMixed effects modeling revealed that compared with an active control condition, TranS‐C resulted in a significant reduction in MDD severity at 12‐month follow‐up. A MacArthur mediation analysis conducted to explore alignment between circadian biology and sleep–wake behavior as a mediator of depression severity reduction through 12‐month follow‐up revealed a significant interaction between change in alignment between circadian biology and sleep–wake behavior and treatment arm, indicating that improved alignment between circadian biology and sleep–wake behavior at posttreatment was associated with improvements in depression outcomes at 12‐month follow‐up under the treatment condition.ConclusionsThese results provide novel evidence for improved alignment between circadian biology and sleep–wake behavior as a specific mechanism of depression improvement, provide key clues into the complex relationship between sleep and depression, and have significant clinical implications for adolescents with depression.
登录
查看更多内容
佛波酯与脂肪细胞亚细胞成分结合的胰岛素依赖性改变。
DOI：
10.1016/0006-291x(87)91591-9
发表时间：
1987
影响因子：
3.1
作者：
Pershadsingh,HA;Shade,DL;McDonald,JM
通讯作者：
McDonald,JM
甲苯磺丁脲和格列本脲对大鼠肝细胞溶胶中 cAMP 依赖性蛋白激酶活性的影响
影响因子：
7.7
作者：
S. Okuno;M. Inaba;Y. Nishizawà;A. Inoue;H. Morii
通讯作者：
H. Morii
大鼠脑蛋白激酶 C：海马离散区域的纯化、抗体产生和定量
影响因子：
4.7
作者：
B. Roth;J. P. Mehegan;D. Jacobowitz;F. Robey;M. Iadarola
通讯作者：
M. Iadarola
细胞质钙增加。
DOI：
--
发表时间：
1987
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Nelson,TY;Gaines,KL;Rajan,AS;Berg,M;Boyd3rd,AE
通讯作者：
Boyd3rd,AE
Sangivamycin 是一种核苷类似物，是蛋白激酶 C 的有效抑制剂。
DOI：
--
发表时间：
1988
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Loomis,CR;Bell,RM
通讯作者：
Bell,RM