A 7-d Exercise Program Increases High-Molecular Weight Adiponectin in Obese Adults
A 7-d Exercise Program Increases High-Molecular Weight Adiponectin in Obese Adults
复制标题
DOI：
10.1249/mss.0b013e318228bf85
复制
发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Kirwan, John P.
中科院分区：
文献类型：
--
作者：
Kelly, Karen R.;Blaszczak, Alecia;Kirwan, John P.
KELLY, K. R.、A. BLASZCZAK、J. M. HAUS、A. PATRICK-MELIN、C. E. FEALY、T. P. SOLOMON、M. I. KALINSKI 和 J. P. KIRWAN。 7 天的锻炼计划可增加肥胖成人的高分子量脂联素。医学。科学。体育锻炼，卷。 44，第 1 期，第 69-74 页，2012 年。 目的：高分子量 (HMW) 脂联素是脂联素的生物活性形式，与增强胰岛素敏感性和代谢功能有关。此前，我们发现7天的运动可以改善肥胖受试者的胰岛素敏感性；然而，短期运动训练是否影响肥胖者的 HMW 脂联素尚不清楚。方法：我们检查了连续 7 天有监督的剧烈运动（60 分钟中心点 d(-1)，85% HRmax）对 17 名肥胖个体（年龄 = 55 +/- 3 岁；体重指数 = 33.7 +/- 0.9 kg 中心点 m(-2)）的 HMW 脂联素和瘦素分泌的影响。使用松田指数通过口服葡萄糖耐量试验 (ISIOGTT) 计算胰岛素敏感性。从 ISIOGTT 之前获得的血液样本中定量空腹血浆 HMW 脂联素和瘦素。测试前和测试过程中每 30 分钟测量一次血糖和胰岛素测量值。双能X射线吸收测定法用于测定身体成分，间接量热法用于评估脂肪氧化。结果：干预后，HMW脂联素显着增加（3202 +/- 543 vs 3878 +/- 682 ng center dot mL(-1)，P = 0.02），瘦素减少（36.8 +/- 5.1 vs 31.1 +/- 4.2 mu g center dot mL(-1)，P = 0.03）。此外，我们观察到 ISIOGTT 增加（1.7 +/- 0.3 vs 2.1 +/- 0.3，P = 0.04），曲线下葡萄糖面积减少（30,871 +/- 2105 vs 28,469 +/- 1657 mg 中心点 dL(-1) 3 小时，P = 0.01）。 HMW脂联素的增加与基础脂肪氧化的增加呈正相关（r = 0.57，P = 0.03），与脂肪组织代谢功能的改善一致。结论：数据表明，7 天的运动不仅足以改善胰岛素敏感性和脂肪氧化，而且还可以有利地改变脂肪因子的分泌，而与体重或成分的变化无关。
KELLY, K. R., A. BLASZCZAK, J. M. HAUS, A. PATRICK-MELIN, C. E. FEALY, T. P. SOLOMON, M. I. KALINSKI, and J. P. KIRWAN. A 7-d Exercise Program Increases High-Molecular Weight Adiponectin in Obese Adults. Med. Sci. Sports Exerc., Vol. 44, No. 1, pp. 69-74, 2012. Purpose: High-molecular weight(HMW) adiponectin is the biologically active form of adiponectin and is related to enhanced insulin sensitivity and metabolic function. Previously, we found that 7 d of exercise improves insulin sensitivity in obese subjects; however, whether short-term exercise training affects HMW adiponectin in obese persons is unknown. Methods: We examined the effect of seven consecutive days of supervised vigorous exercise (60 min center dot d(-1), 85% HRmax) on HMW adiponectin and leptin secretion in 17 obese individuals (age = 55 +/- 3 yr; body mass index = 33.7 +/- 0.9 kg center dot m(-2)). Insulin sensitivity was calculated from an oral glucose tolerance test (ISIOGTT) using the Matsuda Index. Fasting plasma HMW adiponectin and leptin were quantified from blood samples obtained before the ISIOGTT. Glucose and insulin measures were obtained before and every 30 min during the test. Dual-energy x-ray absorptiometry was used to determine body composition, and indirect calorimetry was used to assess fat oxidation. Results: After the intervention, there was a significant increase in HMW adiponectin (3202 +/- 543 vs 3878 +/- 682 ng center dot mL(-1), P = 0.02) and a decrease in leptin (36.8 +/- 5.1 vs 31.1 +/- 4.2 mu g center dot mL(-1), P = 0.03). Further, we observed an increase in ISIOGTT (1.7 +/- 0.3 vs 2.1 +/- 0.3, P = 0.04) and a decrease in glucose area under the curve (30,871 +/- 2105 vs 28,469 +/- 1657 mg center dot dL(-1) for 3 h, P = 0.01). The increase in HMW adiponectin was positively associated with the increase in basal fat oxidation (r = 0.57, P = 0.03), consistent with an improvement in adipose tissue metabolic function. Conclusions: The data suggest that 7 d of exercise is sufficient not only to improve insulin sensitivity and fat oxidation but also to favorably alter adipokine secretion, independent of changes in body weight or composition.