Mitochondria focused neurotherapeutics for spinal cord injury.
Mitochondria focused neurotherapeutics for spinal cord injury.
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DOI：
10.1016/j.expneurol.2020.113332
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发表时间：
2020-08
影响因子：
5.3
通讯作者：
Patel, Samir P.
中科院分区：
文献类型：
--
作者：
Rabchevsky, Alexander G.;Michael, Felicia M.;Patel, Samir P.
The mitochondrion is a double membrane structured organelle involved in a variety of regulatory functions such as calcium signaling, production of adenosine triphosphate, apoptosis, reactive oxygen species generation, cell growth, and cell cycling. Impaired mitochondrial function is evident in various neurological disorders stemming from both acute and chronic neural injury. Herein, we review the role of mitochondrial regulation in maintaining cellular homeostasis, the consequences of their dysfunction in relation to pathophysiology after neurotrauma, approaches being used to promote their bioenergetic integrity for neuroprotection, and multifaceted methods being used to preserve/rescue their function following both traumatic brain and spinal cord injury.
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16.2
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Beckervordersandforth R;Ebert B;Schäffner I;Moss J;Fiebig C;Shin J;Moore DL;Ghosh L;Trinchero MF;Stockburger C;Friedland K;Steib K;von Wittgenstein J;Keiner S;Redecker C;Hölter SM;Xiang W;Wurst W;Jagasia R;Schinder AF;Ming GL;Toni N;Jessberger S;Song H;Lie DC
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2.9
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通讯作者：
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3.7
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Carthy, CM;Yanagawa, B;McManus, BM
通讯作者：
McManus, BM