Incidence of basal cell and squamous cell carcinomas in a population younger than 40 years
Incidence of basal cell and squamous cell carcinomas in a population younger than 40 years
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DOI：
10.1001/jama.294.6.681
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发表时间：
2005-08-10
影响因子：
120.7
通讯作者：
Roenigk, RK
中科院分区：
文献类型：
--
作者：
Christenson, LJ;Borrowman, TA;Roenigk, RK
背景非黑色素瘤皮肤癌的发病率在老年人中迅速增加，但对40岁以下人群的发病率知之甚少。目的估计明尼苏达州奥姆斯特德县40岁以下人群中基底细胞癌和鳞状细胞癌的性别和年龄特异性发病率，并评估发病率随时间的变化;描述这些肿瘤的临床表现、复发和转移率以及组织学特征。设计基于人群的回顾性发病病例回顾。通过罗切斯特流行病学项目获得的具有全面医疗记录的人群。参与者年龄小于40岁的基底细胞癌或鳞状细胞癌患者结果在研究期间，417例患者中诊断出451例基底细胞癌，68例患者中诊断出70例鳞状细胞癌。在这些肿瘤中，328例为组织学证实的基底细胞癌，51例为组织学证实的鳞状线圈癌。总的来说，每100000人中基底细胞癌的年龄校正发病率为女性25.9（95%置信区间[CI]，22.6-29.2），男性20.9（95% CI，17.8-23.9）。女性基底细胞癌的发病率在研究期间显著增加（P
Context The incidence of nonmelanoma skin cancer is increasing rapidly among elderly persons, but little is known about its incidence in the population younger than 40 years.Objectives To estimate the sex- and age-specific incidences of basal cell carcinoma and squamous cell carcinoma in persons younger than 40 years in Olmsted County, Minnesota, and to evaluate change in incidence over time; to describe the clinical presentation, rate of recurrence and metastasis, and histologic characteristics of these tumors in this population-based sample.Design Population-based retrospective incidence case review.Setting Residents of Olmsted County, Minnesota, a population with comprehensive medical records captured through the Rochester Epidemiology Project.Participants Patients younger than 40 years with basal cell carcinoma or squamous cell carcinoma diagnosed between 1976 and 2003.Main Outcome Measures Incident basal cell carcinomas and squamous cell carcinomas and change in incidence of these tumors over time.Results During the study period, 451 incident basal cell carcinomas were diagnosed in 417 patients and 70 incident squamous cell carcinomas were diagnosed in 68 patients. Of these tumors, 328 were histologically confirmed basal cell carcinomas and 51 were histologically confirmed squamous coil carcinomas. Overall, the age-adjusted incidence of basal cell carcinoma per 100000 persons was 25.9 (95% confidence interval [CI], 22.6-29.2) for women and 20.9 (95% Cl, 17.8-23.9) for men. The incidence of basal cell carcinoma increased significantly during the study period among women (P