STUDIES ON ESSENTIAL FATTY ACID DEFICIENCY - EFFECT OF DEFICIENCY ON LIPIDS IN VARIOUS RAT TISSUES + INFLUENCE OF DIETARY SUPPLEMENTATION WITH ESSENTIAL FATTY ACIDS ON DEFICIENT RATS
STUDIES ON ESSENTIAL FATTY ACID DEFICIENCY - EFFECT OF DEFICIENCY ON LIPIDS IN VARIOUS RAT TISSUES + INFLUENCE OF DIETARY SUPPLEMENTATION WITH ESSENTIAL FATTY ACIDS ON DEFICIENT RATS
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DOI：
10.1042/bj0930492
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发表时间：
1964-01-01
影响因子：
4.1
通讯作者：
BARTLEY, W
中科院分区：
文献类型：
--
作者：
BIRAN, LA;RENSHAW, A;BARTLEY, W
大鼠饮食中必需脂肪酸的缺乏导致含氮磷脂和心磷脂组分的组成脂肪酸发生显着变化。在前者中，花生四烯酸和亚油酸被棕榈油酸、油酸和二十碳三烯酸取代。在心磷脂部分中，亚油酸通常是主要的不饱和脂肪酸，膳食缺乏导致这种酸被棕榈油酸、油酸和二十碳三烯酸替代，花生四烯酸在较小程度上被替代。必需脂肪酸的饮食缺乏导致亚油酸的比例下降，棕榈油酸，油酸和二十碳三烯酸的比例上升，在心脏，肾脏和肝脏的中性脂质组分进行比较时，与相应的值为牲畜饲养的动物。花生四烯酸在除脑外的大多数正常组织的中性脂质中所占的比例很低，其含量几乎不受饮食缺乏的影响。用玉米油对动物进行为期16天的营养补充可逆转由心脏、肾脏和肝脏的脂肪酸成分缺乏引起的变化。
Deficiency of essential fatty acids in the diet of the rat resulted in marked changes in constituent fatty acids of the nitrogenous-phospholipid and cardiolipin fractions. In the former there is a replacement of arachidonic acid and linoleic acids by palmitoleic acid, oleic acid and eicosatrienoic acids. In the cardiolipin fraction, where linoleic acid is normally the predominant unsaturated fatty acid, dietary deficiency results in replacement of this acid and to a less extent of arachidonic acid by palmitoleic acid, oleic acid and eicosatrienoic acid. Dietary deficiency of essential fatty acids resulted in a fall in the proportion of linoleic acid and a rise in those of palmitoleic acid, oleic acid and eicosatrienoic acid in the neutral-lipid fractions of heart, kidney and liver when comparison is made with the corresponding values for stock-fed animals. The proportion of arachidonic acid, which is low in the neutral lipids of most normal tissues except brain, are little changed as a result of dietary deficiency. mentation of animals with corn oil over a period of 16 days reversed Dietary supplementation of animals with corn oil over aperiod of 16 days reversed the changes induced by deficiency in the fatty acid constituents of the heart, kidney and liver.