Stage D1 prostate cancer treated by radical prostatectomy and adjuvant hormonal treatment. Evidence for favorable survival in patients with DNA diploid tumors
Stage D1 prostate cancer treated by radical prostatectomy and adjuvant hormonal treatment. Evidence for favorable survival in patients with DNA diploid tumors
复制标题
D1 期前列腺癌采用根治性前列腺切除术和辅助激素治疗。
作者：
H. Zincke;E. Bergstralh;J. J. Larson;G. Farrow;R. Myers;M. Lieber;D. M. Barrett;C. C. Rife;N. Gonchoroff
背景资料。在接受双侧盆腔淋巴清扫和根治性耻骨后前列腺癌切除术(RRP)的临床局限性前列腺癌(PC)患者中，至少每6名患者中就有1例发现DL期疾病。以前对DL期疾病采用手术、放疗或单纯系统治疗的单一疗法的建议通常与进展和生存方面的不良结局相关。与其他病理分期不同，D1期RRP治疗主要与所有终点(进展和生存)和即刻辅助激素治疗(AHT)的DNA倍体模式有关，而与通常的病理变量(包括阳性结节数)无关。
Background. Stage Dl disease is found in at least every sixth patient undergoing bilateral pelvic lymphadenectomy and radical retropubic prostatectomy (RRP) for clinically localized prostate cancer (PC). Previous recommendations for monotherapy using surgery, radiation, or systemic therapy alone for Stage Dl disease have usually been associated with a poor outcome in regard to progression and survival. Unlike other pathologic stages, D1 disease treated with RRP is mainly related to DNA ploidy pattern in regard to all end points (progression and survival) and immediate adjuvant hormonal treatment (AHT) rather than to the usual pathologic variables, including the number of positive nodes.
肿瘤大小与单独手术或联合辅助化疗的转移性前列腺癌治愈率之间的关系。
DOI：
10.1016/s0022-5347(17)42800-x
发表时间：
1988
期刊：
The Journal of urology
影响因子：
--
作者：
Henry,JM;Isaacs,JT
通讯作者：
Isaacs,JT