A new class of C-elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of ras signaling
A new class of C-elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of ras signaling
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DOI：
10.1016/s1534-5807(04)00065-6
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发表时间：
2004-04-01
影响因子：
11.8
通讯作者：
Horvitz, HR
中科院分区：
文献类型：
--
作者：
Ceol, CJ;Horvitz, HR
A类和B类synMuv基因是Ras信号通路的功能冗余负调控因子，其诱导C.秀丽隐翅虫外阴发育。许多B类synMuv基因编码Rb和组蛋白脱乙酰酶复合物的组分，其可能起抑制外阴诱导所需基因转录的作用。我们发现了一类新的synMuv基因，它与A和B类基因在外阴细胞命运决定中发挥冗余作用。这些新的C类synMuv基因编码TRRAP、MYST家族组蛋白乙酰转移酶和Polycomb增强子同源物，它们形成了一个假定的C。Tip 60/NuA 4样组蛋白乙酰转移酶复合物。具有部分C类synMuv特性的第四个基因编码哺乳动物SWI/SNF家族ATP酶p400的同源物。我们的研究结果表明，协调行动的两个染色质修饰复合物，一个与组蛋白去乙酰化酶和组蛋白乙酰转移酶的活性，是重要的调节Ras信号和指定细胞的命运，在C。elegans发育
The class A and class B synMuv genes are functionally redundant negative regulators of a Ras signaling pathway that induces C. elegans vulval development. A number of class B synMuv genes encode components of an Rb and histone deacetylase complex that likely acts to repress transcription of genes required for vulval induction. We discovered a new class of synMuv genes that acts redundantly with both the A and B classes of genes in vulval cell-fate determination. These new class C synMuv genes encode TRRAP, MYST family histone acetyltransferase, and Enhancer of Polycomb homologs, which form a putative C. elegrans Tip60/NuA4-like histone acetyltransferase complex. A fourth gene with partial class C synMuv properties encodes a homolog of the mammalian SWI/SNF family ATPase p400. Our findings indicate that the coordinated action of two chromatin-modifying complexes, one with histone deacetylase and the other with histone acetyltransferase activity, is important in regulating Ras signaling and specifying cell fates during C. elegans development.