Amygdalotrigeminal projection in the rat: An anterograde tracing study
Amygdalotrigeminal projection in the rat: An anterograde tracing study
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DOI：
10.1016/j.aanat.2010.12.004
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发表时间：
2011-01-01
影响因子：
2.2
通讯作者：
Wree, Andreas
中科院分区：
文献类型：
--
作者：
Lazarov, Nikolai E.;Usunoff, Kamen G.;Wree, Andreas
以往的神经生理学研究表明，杏仁核对三叉神经运动神经元的活动有直接的影响。用神经解剖示踪剂生物素葡聚糖胺（BDA）顺行追踪证实了大鼠杏仁三叉神经直接通路的存在。后同侧BDA应用于中央核的杏仁核（AmCe），广泛的同侧投影出现从其内侧亚核被追踪到三叉神经脑干核复合体，包括主感觉（Pr5）和中脑三叉神经核（Me5），和它们的前运动神经元和中间神经元，位于三叉神经上，三叉神经间和三叉神经周围核。在对侧三叉神经脊束核的Pr5、极间亚核和尾侧亚核内也有稀疏的BDA标记轴突及其终末分布。中央外侧杏仁核产生一个轻的同侧投射到脑桥部分的Me5。目前的数据表明，AmCe发送大量的传出到脑干中的三叉神经核，其中其内侧亚核向它们发送主要的输入。内侧杏仁核稀疏支配Me5神经元，特别是那些位于其中脑部分，而基底内侧和基底外侧传出神经不针对三叉神经核复合体。这些结果提示杏仁核输入可能调节三叉神经感觉和运动神经元的活动，杏仁核可能参与咀嚼行为的控制。(C)2011年Elsevier GmbH。All rights reserved.
Previous neurophysiological studies have demonstrated that the amygdala has a direct influence upon trigeminal motoneuron activity. The existence of a direct amygdalotrigeminal pathway in rats was proved by anterograde tracing with the neuroanatomical tracer, biotinylated dextran amine (BDA). After ipsilateral BDA application to the central nucleus of the amygdala (AmCe), widespread ipsilateral projections emerging from its medial subnucleus were traced to the trigeminal brainstem nuclear complex, including the principal sensory (Pr5) and mesencephalic trigeminal nucleus (Me5), and their premotoneurons and interneurons, located in the supratrigeminal, intertrigeminal and peritrigeminal nuclei. Sparse BDA-labeled axons and their terminals were also distributed in the contralateral Pr5, interpolar and caudal subnuclei of the spinal trigeminal nucleus. The central lateral amygdaloid nucleus gives rise to a light ipsilateral projection to the pontine part of the Me5. The present data indicate that AmCe sends massive efferents to the trigeminal nuclei in the brainstem, wherein its medial subnucleus sends the major input to them. The medial amygdaloid nucleus sparsely innervates Me5 neurons, specifically those located in its mesencephalic portion, while basomedial and basolateral efferents do not target the trigeminal nuclear complex. These results suggest that the amygdaloid input may modulate the activity of trigeminal sensory and motor neurons and, thus, the amygdala is possibly involved in the control of masticatory behavior. (C) 2011 Elsevier GmbH. All rights reserved.