Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment.
Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment.
复制标题
利用肿瘤微环境增强抗癌治疗的纳米颗粒设计策略
DOI：
10.1039/c6cs00592f
复制
发表时间：
2017-06-21
影响因子：
46.2
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Dai Y;Xu C;Sun X;Chen X
纳米载体可以有效地携带和递送抗癌剂到肿瘤部位。与正常组织相比，肿瘤微环境具有一些独特的性质，例如血管异常，缺氧和酸性pH。有许多类型的细胞，包括肿瘤细胞，巨噬细胞，免疫和成纤维细胞，由实体瘤中有缺陷的血管喂养。利用肿瘤微环境可以有利于纳米颗粒的设计，以提高治疗效果。在这篇综述文章中，我们总结了各种纳米制剂用于癌症治疗的最新进展，特别强调了肿瘤微环境刺激响应的纳米制剂。许多肿瘤微环境调节策略具有很好的癌症治疗效果，也得到了强调。最后，对未来设计的挑战和机遇进行了详细的讨论。我们相信这些肿瘤微环境调节策略为纳米颗粒配方的实际转化提供了很好的机会。利用肿瘤微环境可以有利于纳米材料的设计，以提高治疗效果。
Nanovehicles can efficiently carry and deliver anticancer agents to tumour sites. Compared with normal tissue, the tumour microenvironment has some unique properties, such as vascular abnormalities, hypoxia and acidic pH. There are many types of cells including tumour cells, macrophages, immune and fibroblasts cells, fed by defective blood vessels in the solid tumour. Exploiting the tumour microenvironment can benefit the design of nanoparticles for enhanced therapeutic effectiveness. In this review article, we summarized the recent progress in various nanoformulations for cancer therapy, with special emphasis on tumour microenvironment stimuli-responsive ones. Numerous tumour microenvironment modulation strategies with promising cancer therapeutic efficacy have also been highlighted. Future challenges and opportunities of design consideration are also discussed in details. We believe that these tumour microenvironment modulation strategies offer a good chance for the practical translation of nanoparticle formulas into clinic. Exploiting the tumour microenvironment can benefit the design of nanomaterials for enhanced therapeutic effectiveness.
登录
查看更多内容
影响因子：
4.9
作者：
Alexis F;Pridgen E;Molnar LK;Farokhzad OC
通讯作者：
Farokhzad OC
影响因子：
15
作者：
Cai, Kaimin;He, Xi;Cheng, Jianjun
通讯作者：
Cheng, Jianjun
影响因子：
6.4
作者：
Banerjee K;Resat H
通讯作者：
Resat H
影响因子：
14
作者：
Alshamsan, Aws;Hamdy, Samar;Uludag, Hasan
通讯作者：
Uludag, Hasan
影响因子：
4
作者：
Balkwill, Frances R.;Capasso, Melania;Hagemann, Thorsten
通讯作者：
Hagemann, Thorsten