Fear is only as deep as the mind allows A coordinate-based meta-analysis of neuroimaging studies on the regulation of negative affect
Fear is only as deep as the mind allows A coordinate-based meta-analysis of neuroimaging studies on the regulation of negative affect
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DOI：
10.1016/j.neuroimage.2011.05.073
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发表时间：
2011-09-01
期刊：
影响因子：
5.7
通讯作者：
Gruber, Oliver
中科院分区：
文献类型：
--
作者：
Diekhof, Esther Kristina;Geier, Katharina;Gruber, Oliver
人类有控制负面情绪和感知到的恐惧的能力。然而，这种情绪调节能力是否依赖于不同实验领域中的一种共同神经机制仍不清楚。在此，我们试图确定在恐惧消退、安慰剂和认知情绪调节领域中调节性大脑激活的共性。利用基于坐标的激活似然估计元分析，我们旨在阐明当人类受试者成功减轻负面情绪时，这三个实验领域中一致的过度激活以及相关的去激活情况。我们的数据显示，只有腹内侧前额叶皮层（VMPFC）的一个区域控制负面情感反应，并降低主观感知到的不愉快程度，且不受实验领域的影响。这种负面情绪的下调还伴随着左侧杏仁核激活的一致减少。安慰剂治疗和认知重评策略的舒缓作用，但不是消退提取，特别伴随着前扣带回和岛叶皮层的一致过度激活。总体而言，我们的数据有力地表明，人类的VMPFC可能代表一种感知恐惧和厌恶的通用领域控制器，它调节情绪处理系统中在系统发育上更古老结构中的负面情感反应。此外，更高层次的调节策略可能进一步利用互补的神经资源来有效应对引发情绪的事件。（C）2011爱思唯尔公司。保留所有权利。
Humans have the ability to control negative affect and perceived fear. Nevertheless, it is still unclear whether this affect regulation capacity relies on a common neural mechanism in different experimental domains. Here, we sought to identify commonalities in regulatory brain activation in the domains of fear extinction, placebo, and cognitive emotion regulation. Using coordinate-based activation-likelihood estimation meta-analysis we intended to elucidate concordant hyperactivations and the associated deactivations in the three experimental domains, when human subjects successfully diminished negative affect. Our data show that only one region in the ventromedial prefrontal cortex (VMPFC) controlled negative affective responses and reduced the degree of subjectively perceived unpleasantness independent of the experimental domain. This down-regulation of negative affect was further accompanied by a concordant reduction of activation in the left amygdala. the soothing effect of placebo treatments and cognitive reappraisal strategies, but not extinction retrieval, was specifically accompanied by a coherent hyperactivation in the anterior cingulate and the insular cortex. Collectively, our data strongly imply that the human VMPFC may represent a domain-general controller of perceived fear and aversiveness that modulates negative affective responses in phylogenetically older structures of the emotion processing system. In addition, higher-level regulation strategies may further engage complementary neural resources to effectively deal with the emotion-eliciting events. (C) 2011 Elsevier Inc. All rights reserved.