Is there any possibility of fertility-sparing surgery in patients with clear-cell carcinoma of the ovary?
Is there any possibility of fertility-sparing surgery in patients with clear-cell carcinoma of the ovary?
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DOI：
10.1016/j.ygyno.2008.04.001
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发表时间：
2008-12-01
影响因子：
4.7
通讯作者：
Kikkawa, Fumitaka
中科院分区：
文献类型：
--
作者：
Kajiyama, Hiroaki;Shibata, Kiyosumi;Kikkawa, Fumitaka
背景资料。在上皮性卵巢癌(EOC)中，保留生育能力的手术(FSS)主要用于IA期疾病。这项研究的目的是阐明卵巢透明细胞癌(CCC)患者的临床结果，这些患者通常接受根治性手术。在对1988-2005年间多个机构的中央病理回顾和医疗记录进行检索后，本研究共对10例接受FSS治疗的CCC患者进行了回顾性评估。年龄32~39岁，平均35.9岁。中位随访时间为35.4月(21.7~153.2个月)。IA期4例，IC期6例(IC(B)期5例，IC(2)期1例)。9例患者接受了辅助化疗。随访36.8个月，9例存活，1例IC(2)期死亡。4例患者观察到5次妊娠。尽管目前还没有针对CCC患者的FSS的全球标准，但似乎在特定的患者中，这种手术方式是可以采用的。这应该通过更大系列的其他研究来进行调查。(C)2008 Elsevier Inc.保留所有权利。
Background. In epithelial ovarian cancer (EOC), fertility-sparing surgery (FSS) has mainly been chosen for stage IA disease. The purpose of this Study was to clarify the clinical Outcome of patients with clear-cell carcinoma of the ovary (CCC) who would usually undergo radical surgery.Cases. After a central pathological review and search of the medical records from multiple institutions between 1988 and 2005, a total of 10 CCC patients treated with FSS were retrospectively evaluated in the current study. The mean age was 35.9 years (range: 32-39 years). The median follow-up time was 35.4 months (range: 21.7-153.2 months). The stage was IA in 4 patients, and IC in 6 patients {IC(b) in 5 patients, and IC(2) in ones}. Nine patients received adjuvant chemotherapy. Nine patients were alive and one patient with stage IC(2) died of the disease at a follow-up time of 36.8 months. Five pregnancies were observed in 4 patients.Conclusions. Although there is no worldwide criterion for FSS in CCC patients at present, it seems that, in selected patients, this Surgical approach could be adopted. This should be investigated by additional studies in a larger series. (C) 2008 Elsevier Inc. All rights reserved.