Acute myelitis after asthma attacks with onset after puberty
Acute myelitis after asthma attacks with onset after puberty
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青春期后发病的哮喘发作后急性脊髓炎
DOI：
10.1136/jnnp.68.5.665
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
J. Kira
中科院分区：
文献类型：
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作者：
I. Horiuchi;K. Yamasaki;M. Osoegawa;Y. Ohyagi;A. Okayama;T. Kurokawa;Takeshi Yamada;J. Kira
在哮喘发作后发现了一种类似脊髓灰质炎的疾病，称为哮喘性肌萎缩（霍普金斯综合征）。以前报告的所有病例都在13岁以下。三名患者在15岁、22岁和73岁时哮喘发作后发生急性肌无力。所有患者均表现为急性弛缓性单肢轻瘫，针极肌电图显示相关肌肉的失神经电位。此外，在两个成年患者的感觉或锥体束参与，诱发电位研究证实了锥体束参与其中之一。这位22岁的患者在另一次哮喘发作后另一肢出现了第二次单轻瘫发作。所有3例患者的抗病毒抗体滴度均无显著变化，但每例患者均出现高IgE血症和过敏原特异性IgE。这些发现表明，哮喘性肌萎缩可在青春期后发生，成年后发生这种疾病的患者似乎显示脊髓的广泛受累和更多样化的病程。
A poliomyelitis-like illness after asthma attacks has been found and is called asthmatic amyotrophy (Hopkins' syndrome). All of the previously reported cases were under 13 years of age. Three patients are described who developed acute myelitis after asthma attacks at 15, 22, and 73 years of age. All of them showed acute flaccid monoparesis, and needle EMG disclosed denervation potentials in the relevant muscles. In addition, in the two adult patients the sensory or pyramidal tracts were involved, and evoked potential studies confirmed an involvement of the pyramidal tracts in one of them. This 22 year old patient showed a second episode of monoparesis in the other limb after another asthma attack. All three patients had no significant changes in their antiviral antibody titres, whereas every patient had hyperIgEaemia and allergen specific IgE. These findings suggest that asthmatic amyotrophy can develop after puberty and that patients who develop this disease in adulthood seem to show both a widespread involvement of the spinal cord and a more varied course.