Reduction of nocturnal rise in bone resorption by subcutaneous GLP-2
Reduction of nocturnal rise in bone resorption by subcutaneous GLP-2
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DOI：
10.1016/j.bone.2003.09.009
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发表时间：
2004-01-01
期刊：
影响因子：
4.1
通讯作者：
Holst, JJ
中科院分区：
文献类型：
--
作者：
Henriksen, DB;Alexandersen, P;Holst, JJ
我们以前已经表明，在空腹绝经后妇女中，在上午9点皮下注射胰高血糖素样肽-2（GLP-2）导致血清中I型胶原蛋白（s-CTX）C末端肽区（骨吸收的标志物）降解产生的片段浓度呈剂量依赖性降低。相反，GLP-2被发现对骨形成具有中性作用，如通过血清骨钙素所评估的。由于增加的s-CTX水平通常在夜间观察到，我们进行了健康的绝经后妇女睡前研究。目的是研究睡前给予GLP-2注射对骨转换的影响。两项随机安慰剂对照研究共纳入81名绝经后女性。总之，我们发现注射GLP-2后sCTX的剂量相关性降低（P < 0.05），并且与安慰剂相比，骨钙素水平通过治疗增加（P = 0.07），表明对骨形成的刺激作用。GLP-2注射后s-CTX的曲线下面积（AUC（0-10 h））分析证实了与安慰剂相比的剂量相关性降低（P < 0.05）。(C)2003年爱思唯尔公司All rights reserved.
We have previously shown that a subcutaneous injection of glucagon-like peptide-2 (GLP-2) at 9 a.m. in fasting postmenopausal women results in a dose-dependent decrease in the serum concentration of fragments derived from the degradation of the C-terminal telopeptide region of collagen type I (s-CTX), a marker of bone resorption. In contrast, GLP-2 was found to have a neutral effect on bone formation, as assessed by serum osteocalcin. Since increased s-CTX levels are normally observed at night, we conducted bedtime studies in healthy postmenopausal women. The objective was to study the effect of GLP-2 injection on bone turnover given at bedtime. A total of 81 postmenopausal women were included in two randomised placebo-controlled studies. In conclusion, we found a dose-related reduction of sCTX after injection of GLP-2 (P < 0.05) and osteocalcin levels was increased as compared to placebo (P = 0.07) by the treatment, suggestive of a stimulative effect on bone formation. An area under the curve (AUC(0-10 h)) analysis for s-CTX after GLP-2 injection confirmed the dose-related decrease as compared to placebo (P < 0.05). (C) 2003 Elsevier Inc. All rights reserved.