Prune fiber or pectin compared with cellulose lowers plasma and liver lipids in rats with diet-induced hyperlipidemia.
Prune fiber or pectin compared with cellulose lowers plasma and liver lipids in rats with diet-induced hyperlipidemia.
复制标题
与纤维素相比，西梅纤维或果胶可降低饮食引起的高脂血症大鼠的血浆和肝脏脂质。
DOI：
10.1093/jn/124.1.31
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
B. Schneeman
中科院分区：
文献类型：
--
作者：
Lesley F. Tinker;P. Davis;B. Schneeman
先前的研究表明，高胆固醇血症男性饮食中的李子可以降低血浆和低密度脂蛋白的浓度。为了进一步研究摄入李子后的脂质代谢，我们进行了一项动物研究，以检验从李子中提取的纤维与纯化的纤维素相比，降低饮食诱导的高脂血症大鼠的血浆和肝脏胆固醇的假设，并且这种反应是剂量依赖的。大鼠被随机分配到五个实验饮食组中的一个。其中四种饮食含有胆固醇和胆酸，以诱导高脂血症。高脂饲料中纤维来源为6%纤维素、3%李子纤维、6%李子纤维或3%果胶。第五组，非高脂血症对照组，饲喂含有6%纤维素的饲料，不含胆固醇或胆酸。大鼠自由饮用5种饲料中的一种28d，16h后空腹处死。高脂对照组大鼠的血浆、低密度脂蛋白和肝脏胆固醇浓度高于非高脂对照组，而添加果胶或李子纤维的饲料组大鼠的血浆、低密度脂蛋白和肝脏胆固醇浓度低于高脂对照组。在饲喂剂量水平的李子纤维或饲喂6%的李子纤维和果胶的组之间，没有发现血浆或肝脏胆固醇浓度的差异。这些结果表明，从李子中提取的纤维降低了高脂血症大鼠的血浆和肝脏胆固醇，尽管没有检测到剂量依赖的反应。
Previous research indicated that prunes in the diet of men with hypercholesterolemia lowered plasma and LDL cholesterol concentrations. To further study lipid metabolism in response to ingesting prunes, we conducted an animal study to test the hypotheses that fiber extracted from prunes, compared with purified cellulose, lowers plasma and liver cholesterol in rats with diet-induced hyperlipidemia and that the response is dose dependent. Rats were randomly assigned to one of five experimental diet groups. Four of the diets contained cholesterol and cholic acid to induce hyperlipidemia. The fiber source in the hyperlipidemic diets was 6% cellulose, 3% prune fiber, 6% prune fiber or 3% pectin. The fifth group, the nonhyperlipidemic control, was fed a diet containing 6% cellulose without cholesterol or cholic acid. Rats consumed one of the five diets ad libitum for 28 d, then were killed after 16 h without food. Plasma, LDL and liver cholesterol concentrations were higher in the hyperlipidemic control than the nonhyperlipidemic control and lower in the groups fed diets containing pectin or prune fiber than in the hyperlipidemic control group. No differences in plasma or liver cholesterol concentrations were detected between groups fed either dose level of prune fiber or between groups fed 6% prune fiber and pectin. These results indicate that fiber extracted from prunes lowers plasma and liver cholesterol in hyperlipidemic rats, although a dose-dependent response was not detected.