Adaptive immune responses mediated by natural killer cells.
Adaptive immune responses mediated by natural killer cells.
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DOI：
10.1111/j.0105-2896.2010.00906.x
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发表时间：
2010-05
影响因子：
8.7
通讯作者：
von Andrian UH
中科院分区：
文献类型：
--
作者：
Paust S;Senman B;von Andrian UH
适应性免疫传统上被认为是脊椎动物生理学的独特特征。与先天性免疫反应不同，先天性免疫反应在受到相同刺激的反复挑战后基本保持不变，而适应性免疫细胞具有学习和记忆的能力。因此，对先前遇到的挑战的二次适应性反应在质量和/或数量上与初次遭遇引起的反应不同。除了获得长期记忆的能力之外，适应性免疫的第二个主要特征是抗原特异性。人们普遍认为，只有T细胞和B细胞能够形成抗原特异性免疫记忆，因为这些淋巴细胞独特地表达重组激活基因(RAG)蛋白，这是V(D)J基因片段体细胞重排以组装不同抗原特异性受体所必需的。然而，最近的工作发现了小鼠自然杀伤（NK）细胞的离散子集，它们能够介导对各种基于半抗原的接触敏化剂的长期、抗原特异性回忆反应。这些 NK 细胞似乎使用独特的、不依赖于 RAG 的机制来产生抗原特异性。最近也显示小鼠 NK 细胞在病毒感染后会产生记忆。在这里，我们回顾了最近的证据，表明至少一些 NK 细胞能够介导适应性免疫，并讨论可能有助于不依赖 RAG 产生抗原多样性和寿命的潜在机制。
Adaptive immunity has traditionally been considered a unique feature of vertebrate physiology. Unlike innate immune responses, which remain essentially unchanged upon exposure to a recurrent challenge with the same stimulus, adaptive immune cells possess the ability to learn and remember. Thus, secondary adaptive responses to a previously encountered challenge are qualitatively and/or quantitatively distinct from those elicited by a primary encounter. Besides this capacity to acquire long-lived memory, the second cardinal feature of adaptive immunity is antigen specificity. It has been generally believed that only T and B cells can develop antigen-specific immunological memory, because these lymphocytes uniquely express recombination-activating gene (RAG) proteins, which are necessary for somatic rearrangement of V(D)J gene segments to assemble diverse antigen-specific receptors. However, recent work has uncovered discrete subsets of murine natural killer (NK) cells capable of mediating long-lived, antigen-specific recall responses to a variety of hapten-based contact sensitizers. These NK cells appear to use distinct, RAG-independent mechanisms to generate antigen specificity. Murine NK cells have also recently been shown to develop memory upon viral infection. Here, we review recent evidence indicating that at least some NK cells are capable of mediating what appears to be adaptive immunity and discuss potential mechanisms that may contribute to RAG-independent generation of antigenic diversity and longevity.
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DOI：
10.1084/jem.187.2.197
发表时间：
1998-01-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Diacovo TG;Catalina MD;Siegelman MH;von Andrian UH
通讯作者：
von Andrian UH
DOI：
10.1073/pnas.0601335103
发表时间：
2006-04-11
影响因子：
11.1
作者：
Bielekova, B;Catalfamo, M;Martin, R
通讯作者：
Martin, R
影响因子：
4.4
作者：
Eidenschenk, Celine;Jouanguy, Enunanuelle;Casanova, Jean-Laurent
通讯作者：
Casanova, Jean-Laurent
影响因子：
4.4
作者：
Draghi, Monia;Pashine, Achal;Parham, Peter
通讯作者：
Parham, Peter
影响因子：
6.5
作者：
Buentke, E;Heffler, LC;Scheynius, A
通讯作者：
Scheynius, A