Glucose Responsive Hydrogel Networks Based on Protein Recognition
Glucose Responsive Hydrogel Networks Based on Protein Recognition
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DOI：
10.1002/mabi.200800337
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发表时间：
2009-09-09
影响因子：
4.6
通讯作者：
Daunert, Sylvia
中科院分区：
文献类型：
--
作者：
Ehrick, Jason D.;Luckett, Matthew R.;Daunert, Sylvia
能够响应于环境信号而表现出物理变化的刺激响应材料是用于各种生物医学应用的有价值的工具。在本文中，我们描述了一种这样的智能葡萄糖响应性水凝胶材料，其通过将葡萄糖/半乳糖结合蛋白固定在丙烯酰胺水凝胶网络内来制备。该水凝胶在葡萄糖存在下表现出定量的“手风琴”样动态响应。我们进一步显示了采用这种响应性智能材料作为受控药物递送的门控剂的可行性，从而表明这些水凝胶可能最终导致糖尿病管理应用的可植入药物递送系统的发展。
Stimuli-responsive materials capable of manifesting physical changes in response to environmental signals are valuable tools for use in a variety of biomedical applications. Herein we describe one such smart glucose-responsive hydrogel material prepared by immobilizing the glucose/galactose binding protein within an acrylamide hydrogel network. This hydrogel demonstrates a quantitative "accordion"-like dynamic response in the presence of glucose. We further show the feasibility of employing this responsive smart material as a gating agent for controlled drug delivery, thus, demonstrating that these hydrogels may eventually lead to the development of implantable drug delivery systems for diabetes management applications.