Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles.

Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles.
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DOI:
10.1186/s11671-018-2728-6
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发表时间:
2018-10-25
影响因子:
--
通讯作者:
Aziz AA
Aziz AA
中科院分区:
材料科学3区
文献类型:
--
作者:
Foroozandeh P;Aziz AA

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纳米粒子科学正在迅速改变各个科学领域的景观,并定义新的技术平台。这在纳米医学领域可能更加明显,其中纳米颗粒已被用作治疗和诊断许多疾病的工具。然而,尽管这项技术带来了巨大的好处,但其共同的陷阱是其对人体的潜在短期和长期影响。为了理解这些问题,已经进行了许多科学研究。这篇综述试图阐明其中的一些研究及其结果。在这次审查的主题包括不同的可能的纳米粒子和细胞内的运输途径的摄取途径。此外,纳米颗粒的物理化学性质,如大小,形状,电荷和表面化学在确定纳米颗粒的摄取机制和生物功能的影响也得到了解决。
Nanoparticle science is rapidly changing the landscape of various scientific fields and defining new technological platforms. This is perhaps even more evident in the field of nanomedicine whereby nanoparticles have been used as a tool for the treatment and diagnosis of many diseases. However, despite the tremendous benefit conferred, common pitfalls of this technology is its potential short and long-term effects on the human body. To understand these issues, many scientific studies have been carried out. This review attempts to shed light on some of these studies and its outcomes. The topics that were examined in this review include the different possible uptake pathways of nanoparticles and intracellular trafficking routes. Additionally, the effect of physicochemical properties of nanoparticle such as size, shape, charge and surface chemistry in determining the mechanism of uptake and biological function of nanoparticles are also addressed.
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