Calcium accretion in girls and boys during puberty: A longitudinal analysis
Calcium accretion in girls and boys during puberty: A longitudinal analysis
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DOI：
10.1359/jbmr.2000.15.11.2245
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发表时间：
2000-11-01
影响因子：
6.2
通讯作者：
Mirwald, R
中科院分区：
文献类型：
--
作者：
Bailey, DA;Heather, ADM;Mirwald, R
本研究的主要目的是评估健康白色青少年骨骼中峰值钙增长率的大小和变异性。通过双能X线吸收法（DXA; Hologic 2000，阵列模式）每年测量6次全身骨矿物质含量（BMC），通过三次样条拟合为每个儿童生成BMC速度曲线，并确定峰值增长率。每6个月收集一次人体测量数据，每年记录两到三次24小时饮食回忆。在最初入组研究的113名男孩和115名女孩中，60名男孩和53名女孩具有峰值身高速度（PHV）和峰值BMC速度值。当个体BR IC速度曲线与峰值骨矿物质速度的年龄一致时，得到的平均峰值骨矿物质增加率为407 g/年（SD，92 g/年;范围，226-651 g/年），男孩为322 g/年（SD，66 g/年;范围，194-520 g/年）。使用32.2%作为骨矿物质中钙的分数，如通过中子活化分析测定的（Ellis等人，J Bone Miner Res 1996;11：843-848），这些对应于男孩359 mg/天（81 mg/天; 199-574 mg/天）和女孩284 mg/天（58 mg/天; 171-459 mg/天）的峰值钙增加速率。这些纵向结果比我们之前的横断面分析高27-34%，在我们之前的横断面分析中，我们报告了男孩的平均值为282 mg/天，女孩为212 mg/天（Martin等人，Am J Clin Nutr 1997;66：611-615）。男孩的峰值钙增加平均年龄为14.0岁（1.0岁; 12.0-15.9岁），女孩为12.5岁（0.9岁; 10.5-14.6岁）。膳食钙摄入量，确定为峰值增长年龄之前所有评估的平均值，男孩为1140 mg/天（SD，392 mg/天），女孩为1113 mg/天（SD，378 mg/天）。我们估计，成人钙的26%是在骨骼生长高峰期的2个青春期沉积的。这一快速生长期需要钙的高增长率，部分是通过增加膳食钙的保留效率来实现的。
The primary purpose of this study was to estimate the magnitude and variability of peak calcium accretion rates in the skeletons of healthy white adolescents. Total-body bone mineral content (BMC) was measured annually on six occasions by dual-energy X-ray absorptiometry (DXA; Hologic 2000, array mode), a BMC velocity curve was generated for each child by a cubic spline fit, and peak accretion rates were determined. Anthropometric measures were collected every 6 months and a 24-h dietary recall was recorded two to three times per year. Of the 113 boys and 115 girls initially enrolled in the study, 60 boys and 53 girls who had peak height velocity (PHV) and peak BMC velocity values were used in this longitudinal analysis. When the individual BR IC velocity curves were aligned on the age of peak bone mineral velocity, the resulting mean peak bone mineral accrual rate was 407 g/year for boys (SD, 92 g/year; range, 226-651 g/year) and 322 g/year for girls (SD, 66 g/year; range, 194-520 g/year). Using 32.2% as the fraction of calcium in bone mineral, as determined by neutron activation analysis (Ellis et al., J Bone Miner Res 1996;11:843-848), these corresponded to peak calcium accretion rates of 359 mg/day for boys (81 mg/day; 199-574 mg/day) and 284 mg/day for girls (58 mg/day; 171-459 mg/day). These longitudinal results are 27-34% higher than our previous cross-sectional analysis in which we reported mean values of 282 mg/day for boys and 212 mg/day for girls (Martin et al., Am J Clin Nutr 1997;66:611-615). Mean age of peak calcium accretion was 14.0 years for the boys (1.0 years; 12.0-15.9 years), and 12.5 years for the girls (0.9 years; 10.5-14.6 years). Dietary calcium intake, determined as the mean of all assessments up to the age of peak accretion was 1140 mg/day (SD, 392 mg/day) for boys and 1113 mg/day (SD, 378 mg/day) for girls. We estimate that 26% of adult calcium is laid down during the 2 adolescent years of peak skeletal growth. This period of rapid growth requires high accretion rates of calcium, achieved in part by increased retention efficiency of dietary calcium.