Physiological and pathological regulation of feto/placento/maternal leptin expression.
Physiological and pathological regulation of feto/placento/maternal leptin expression.
复制标题
胎儿/胎盘/母体瘦素表达的生理和病理调节。
DOI：
10.1042/0300-5127:0290086
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发表时间：
2001
影响因子：
3.9
通讯作者：
C. Fusch
中科院分区：
文献类型：
--
作者：
K. Linnemann;A. Malek;H. Schneider;C. Fusch
有明确的证据表明胎盘瘦素的产生，最近在滋养层培养物和双重体外胎盘灌注中显示（每克组织的平均产量为 225 皮克/分钟；98.4% 释放到母体中，1.6% 释放到胎儿循环中）。然而，对母亲和胎儿的生理影响尚不清楚。瘦素的经典作用是向中枢神经系统提供有关能量存储的信息，并在能量存储已满时降低食欲。在怀孕期间，母体血浆瘦素浓度升高，并且缺乏在非孕妇中观察到的与身体脂肪能量储存的良好相关性，这表明瘦素在怀孕和胎儿发育期间具有替代功能。母体和胎儿血浆瘦素水平在妊娠糖尿病、先兆子痫和子宫内生长迟缓等病理状况下失调，代表胎儿/胎盘/母体单位紊乱的影响或原因。
There is clear evidence of placental leptin production, as shown recently in trophoblast cultures and by dual in vitro placenta perfusion (median production of 225 pg/min per g of tissue; 98.4% released into the maternal and 1.6% into the fetal circulation). However, the physiological impact for the mother and the fetus is unclear. The classical role of leptin is to provide information about energy stores to the central nervous system, and to reduce appetite if the energy stores are full. In pregnancy, maternal plasma leptin concentrations are elevated, and lack the well established correlation with body fat energy stores that is observed in non-pregnant women, indicating an alternative function for leptin during pregnancy and fetal development. Maternal and fetal plasma leptin levels are dysregulated in pathological conditions such as gestational diabetes, pre-eclampsia and intra-uterine growth retardation, representing an effect or a cause of disturbances in the feto/placento/maternal unit.