Characterizing Fixational Eye Motion Variance Over Time as Recorded by the Tracking Scanning Laser Ophthalmoscope.
Characterizing Fixational Eye Motion Variance Over Time as Recorded by the Tracking Scanning Laser Ophthalmoscope.
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DOI：
10.1167/tvst.11.2.35
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发表时间：
2022-02-01
影响因子：
3
通讯作者：
Sheehy CK
中科院分区：
文献类型：
--
作者：
Condor Montes SY;Bennett D;Bensinger E;Rani L;Sherkat Y;Zhao C;Helft Z;Roorda A;Green AJ;Sheehy CK
本研究的目的是利用跟踪扫描激光检眼镜（TSLO）表征对照人群中固定微跳的良性生物学变异，考虑机器精度和精度，以确定检测固定眼动（FEM）病理变化的理想测试条件。我们量化了TSLO的准确度和精度，分析了三位操作员在模型眼上的测量结果。然后在17个对照组中重复记录10秒视网膜运动轨迹，每天3次（上午、下午和晚上），连续3天。提取频率、平均幅值、峰值速度和峰值加速度的微跳频指标。对所有受试者的追踪到追踪、日间和日内变异性进行计算。操作员内部和机器变化对总变化的贡献最小，频率和幅度分别仅为0.007%和0.14%。检测到偏倚，较高的振幅精度较低。参与者的平均微跳频率（SD）为0.84 Hz (0.52 Hz)，幅度为0.32度（0.11度），峰值速度为43.68度/秒（14.02度/秒），峰值加速度为13,920.04度/秒（4,186.84度/秒）。第一次记录的微跳加速度和速度与第二次记录的微跳速度有显著差异（P < 0.05），频率在夜间高0.098 Hz （P < 0.05）。天之间没有MM差异，也没有证据表明存在会话水平的学习效应（P < 0.05）。TSLO既准确又精密。然而，个体间和个体内的生物差异是存在的。应考虑到痕量到痕量的可变性和一天中的时间，以优化病理变化的检测。
The purpose of this study was to characterize the benign biological variance of fixational microsaccades in a control population using a tracking scanning laser ophthalmoscope (TSLO), accounting for machine accuracy and precision, to determine ideal testing conditions to detect pathologic change in fixational eye motion (FEM). We quantified the accuracy and precision of the TSLO, analyzing measurements made by three operators on a model eye. Repeated, 10-second retinal motion traces were then recorded in 17 controls, 3 times a day (morning, afternoon, and evening), on 3 separate days. Microsaccade metrics (MMs) of frequency, average amplitude, peak velocity, and peak acceleration were extracted. Trace to trace, interday, and intraday variability were calculated across all subjects. Intra-operator and machine variation contributed minimally to total variation, with only 0.007% and 0.14% contribution for frequency and amplitude respectively. Bias was detected, with lower accuracy for higher amplitudes. Participants had an average (SD) microsaccade frequency of 0.84 Hz (0.52 Hz), amplitude of 0.32 degrees (0.11 degrees), peak velocity of 43.68 degrees/s (14.02 degrees/s), and peak acceleration of 13,920.04 degrees/s2 (4,186.84 degrees/s2). The first trace recorded within a session significantly differed from the second two in both microsaccade acceleration and velocity (P < 0.05), and frequency was 0.098 Hz higher in the evenings (P < 0.05). There was no MM difference between days and no evidence of a session-level learning effect (P > 0.05). The TSLO is both accurate and precise. However, biological inter- and intra-individual variance is present. Trace to trace variability and time of day should be accounted for to optimize detection of pathologic change.
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影响因子：
3.4
作者：
Alexander RG;Macknik SL;Martinez-Conde S
通讯作者：
Martinez-Conde S
影响因子：
3.4
作者：
Di Stasi, Leandro L.;McCamy, Michael B.;Martinez-Conde, Susana
通讯作者：
Martinez-Conde, Susana
影响因子：
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作者：
Sheehy, Christy K.;Bensinger, Ethan S.;Green, Ari J.
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Green, Ari J.
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作者：
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通讯作者：
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作者：
Abadi, R;Gowen, E
通讯作者：
Gowen, E