Small (≤2-cm) breast cancer treated with US-guided radiofrequency ablation:: Feasibility study
Small (≤2-cm) breast cancer treated with US-guided radiofrequency ablation:: Feasibility study
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DOI：
10.1148/radiol.2311030651
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发表时间：
2004-04-01
期刊：
影响因子：
19.7
通讯作者：
Singletary, SE
中科院分区：
文献类型：
--
作者：
Fornage, BD;Sneige, N;Singletary, SE
目得：为了确定的可行性和安全性的超声（US）引导下经皮射频（RF）消融局部治疗浸润性乳腺癌2厘米或更小的最大diameter.MATERIALS和方法：RF消融21恶性病变进行了20例患者在他们的计划肿块切除术或乳房切除术。将15号针电极放置在病变中，并在实时US引导下展开针电极的尖头。在尖头尖端保持约95 ℃的温度15分钟。切除标本的组织学检查包括使用还原型烟酰胺腺嘌呤二核苷酸-黄递酶染色，其专门用于确认热细胞损伤和缺乏活力。该程序的预期结果是消融肿瘤和足够的边缘周围，证实了没有活组织在手术标本。结果：在所有21例，完全消融的靶病变可视化在US。在1例患者中，该患者因最初被判定为T2肿瘤的肿块接受了术前化疗，但在消融时进行的乳腺X线摄影和超声检查中发现有小的残留肿瘤，靶病变被消融，但在组织病理学检查中发现残留原位乳腺X线摄影和超声隐匿性浸润癌。结论：超声引导下经皮消融治疗小浸润性乳腺癌是安全可行的。(C)RSNA，2004年。
PURPOSE: To determine the feasibility and safety of ultrasonographically (US) guided percutaneous radiofrequency (RF) ablation in the local treatment of invasive breast carcinomas 2 cm or less in greatest diameter.MATERIALS AND METHODS: RF ablation of 21 malignant lesions was performed in 20 patients immediately before their scheduled lumpectomy or mastectomy. A 15-gauge needle electrode was placed in the lesions, and the prongs of the needle electrode were deployed with real-time US guidance. A temperature of approximately 95 degreesC was maintained for 15 minutes at the tips of the prongs. Histopathologic examination of the resected specimens included use of nicotinamide adenine dinucleotide in its reduced form-diaphorase stain, which is specifically used to confirm thermal cell injury and lack of viability. The desired outcome of the procedure was ablation of the tumor and of an adequate margin around it, as confirmed by the absence of viable tissue in the surgical specimen.RESULTS: In all 21 cases, complete ablation of the target lesion was visualized at US. In one patient, who had undergone preoperative chemotherapy for a mass that was initially judged to be a T2 tumor but who was found to have a small residual tumor at mammography and US performed at the time of ablation, the target lesion was ablated but residual in situ mammographically and US occult invasive carcinoma was found at histopathologic examination. There were no adverse effects.CONCLUSION: US-guided percutaneous ablation of small invasive breast carcinomas is feasible and safe. (C) RSNA, 2004.