Does the level of E-cadherin expression correlate with the primary breast carcinoma infiltration pattern and type of systemic metastases?
Does the level of E-cadherin expression correlate with the primary breast carcinoma infiltration pattern and type of systemic metastases?
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DOI：
10.1309/jmrd-w08y-6k8m-7ad8
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发表时间：
2002-09-01
影响因子：
3.5
通讯作者：
Goldstein, NS
中科院分区：
文献类型：
--
作者：
Goldstein, NS
在295例乳腺癌和57例小叶癌系统转移患者中研究了浸润性癌膜E-钙粘蛋白反应性、不良生长模式和小叶癌型系统转移之间的关系。其中单纯小叶癌143例，小叶和导管混合癌80例，单纯导管癌72例。30例以小叶为主的混合型癌中有2例（7%），38例以小叶为主的混合型癌中有23例（61%），12例以导管为主的混合型癌中有8例（67%）的小叶癌细胞中E-cadherin染色超过10%。在45例病例中确定了小叶癌型全身转移（38例[84%]，纯小叶; 5例[11%]，混合; 2例[4%]，纯导管）。在43例小叶癌型全身转移和57例小叶癌全身转移中，42例（98%）未见E-钙粘素染色。缺乏细胞间粘附似乎是癌细胞促进渗透通过组织平面并产生特征性小叶癌型全身转移的必要特性。在原发性乳腺癌中出现异常生长模式的E-钙粘蛋白表达水平降低可能低于小叶癌型全身转移的相关水平。
Relationships between membrane E-cadherin reactivity of invasive carcinoma, a dyshesive growth pattern, and lobular carcinoma-type systemic metastases were studied in 295 breast carcinomas and 57 patients with lobular carcinoma systemic metastases. There were 143 pure lobular carcinomas, 80 mixed (lobular and ductal) carcinomas, and 72 pure ductal carcinomas. Two (7%) of 30 mixed, predominantly lobular carcinomas, 23 (61%) of 38 mixed carcinomas, and 8 (67%) of 12 mixed, predominantly ductal carcinomas had E-cadherin staining in more than 10% of the lobular carcinoma cells. Lobular carcinoma-type systemic metastases were identified in 45 cases (38 [84%], pure lobular; 5 [11%], mixed; 2 [4%], pure ductal). No E-cadherin staining was found in 42 (98%) of 43 lobular carcinomas in cases of lobular carcinoma-type systemic metastases and all 57 cases of lobular carcinoma systemic metastases. Absent cell-to-cell adhesion seems to be a necessary property of carcinoma cells to facilitate permeation through tissue planes and produce characteristic lobular carcinoma-type systemic metastases. The level of decreased E-cadherin expression at which a dyshesive growth pattern emerges in primary breast carcinomas may be less than the level associated with lobular carcinoma-type systemic metastases.